TY - JOUR
T1 - Expanding roles of superoxide dismutases in cell regulation and cancer
AU - Che, Meixia
AU - Wang, Ren
AU - Li, Xiaoxing
AU - Wang, Hui Yun
AU - Zheng, X. F.Steven
N1 - Funding Information:
The work is supported by NIH R01 grants CA123391 , CA166575 and CA173519 (X.F.Z.).
Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Reactive oxygen species (ROS) have important roles in normal physiology and diseases, particularly cancer. Under normal physiological conditions, they participate in redox reactions and serve as second messengers for regulatory functions. Owing to aberrant metabolism, cancer cells accumulate excessive ROS, thus requiring a robustly active antioxidant system to prevent cellular damage. Superoxide dismutases (SODs) are enzymes that catalyze the removal of superoxide free radicals. There are three distinct members of this metalloenzyme family in mammals: SOD1 (Cu/ZnSOD), SOD2 (MnSOD) and SOD3 (ecSOD). SODs are increasingly recognized for their regulatory functions in growth, metabolism and oxidative stress responses, which are also crucial for cancer development and survival. Growing evidence shows that SODs are also potentially useful anticancer drug targets. This review will focus on recent research of SODs in cellular regulation, with emphasis on their roles in cancer biology and therapy.
AB - Reactive oxygen species (ROS) have important roles in normal physiology and diseases, particularly cancer. Under normal physiological conditions, they participate in redox reactions and serve as second messengers for regulatory functions. Owing to aberrant metabolism, cancer cells accumulate excessive ROS, thus requiring a robustly active antioxidant system to prevent cellular damage. Superoxide dismutases (SODs) are enzymes that catalyze the removal of superoxide free radicals. There are three distinct members of this metalloenzyme family in mammals: SOD1 (Cu/ZnSOD), SOD2 (MnSOD) and SOD3 (ecSOD). SODs are increasingly recognized for their regulatory functions in growth, metabolism and oxidative stress responses, which are also crucial for cancer development and survival. Growing evidence shows that SODs are also potentially useful anticancer drug targets. This review will focus on recent research of SODs in cellular regulation, with emphasis on their roles in cancer biology and therapy.
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U2 - 10.1016/j.drudis.2015.10.001
DO - 10.1016/j.drudis.2015.10.001
M3 - Review article
C2 - 26475962
AN - SCOPUS:84960345039
SN - 1359-6446
VL - 21
SP - 143
EP - 149
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 1
ER -
