Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine

Keyphrases

• Metabolism 100%
• Unnatural Amino Acids 100%
• Total Biosynthesis 100%
• Homoalanine 100%
• Glutamate Dehydrogenase 75%
• α-ketobutyrate 50%
• Overexpressing 25%
• Levetiracetam 25%
• Threonine 25%
• Health Care Costs 25%
• Substrate Specificity 25%
• Dehydrogenase 25%
• High Prices 25%
• Selection Strategy 25%
• Metabolic Flexibility 25%
• Brivaracetam 25%
• Valine 25%
• Glucose Yield 25%
• Biosynthesized 25%
• NADH-dependent 25%
• Escherichia Coli Strains 25%
• Kcat 25%
• L-glucose 25%
• Specificity Constant 25%
• Aerobic Conditions 25%
• Transaminases 25%
• α-ketoglutarate (α-KG) 25%
• Bacillus Subtilis (B. subtilis) 25%
• Natural Substrate 25%
• Chiral Molecules 25%
• Ethambutol 25%
• Pharmaceutical Intermediate 25%
• Chiral Precursors 25%
• Conversion Yield 25%
• Environmentally Friendly Approach 25%
• Threonine Dehydratase 25%
• IlvE 25%
• Chiral Drug Intermediate 25%

Chemistry

• Amino Acid 100%
• Glutamic Acid 100%
• Threonine 66%
• Metabolic 33%
• NADH 33%
• Kcat 33%
• Substrate Specificity 33%
• Brivaracetam 33%
• Levetiracetam 33%
• L-Glucose 33%
• Ethambutol 33%
• Valine 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Amino Acid 100%
• Glutamate Dehydrogenase 100%
• Substrate Specificity 33%
• Escherichia coli 33%
• Brivaracetam 33%
• Aminotransferase 33%
• 2 Oxoglutaric Acid 33%
• Valine Dehydrogenase 33%
• Threonine Ammonia Lyase 33%
• Levetiracetam 33%
• Threonine 33%
• Ethambutol 33%