TY - JOUR
T1 - Expanding first-line options for depression
T2 - Protocol of a pragmatic comparative effectiveness trial of yoga vs. behavioral activation (the COMPARE study)
AU - Sylvia, Louisa G.
AU - Busch, Andrew M.
AU - Rabideau, Dustin J.
AU - Gold, Alexandra
AU - Danhauer, Suzanne C.
AU - Schatten, Heather T.
AU - Katz, Douglas
AU - Weinstock, Lauren M.
AU - Dahne, Jennifer
AU - Schmid, Sabine P.
AU - Soetan, Zainab
AU - Tovey, Roberta
AU - Pintro, Kedie
AU - Kvaka, Adrienne
AU - Hernandez, Antonietta Alvarez
AU - Hsu, Ingrid
AU - Melendez, Alba
AU - Adkins-Hempel, Melissa
AU - Grubb, Angela
AU - Lozado, Odalys
AU - Fili, Atefeh Alavi
AU - Chau, Giuliana
AU - Uebelacker, Lisa A.
N1 - Publisher Copyright:
© 2025 Sylvia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2025/1
Y1 - 2025/1
N2 - Depression is a prevalent mental health condition in the United States and a significant cause of morbidity and mortality. The treatment guidelines for depression recommends either psychotherapy, such as behavioral activation (BA), or a second-generation antidepressant as a first-line treatment for adult patients with depression. However, many individuals with depression do not experience improvement from first-line treatments or choose not to engage in them due to stigma, cost, difficulty with access, and/or side effects. As such we need new treatments for depression and yoga is especially promising given recent data on its efficacy for depression. This study seeks to compare a first-line treatment for depression, or BA, versus yoga to examine whether yoga does as well as BA at improving depressive symptoms and secondary outcomes. We will also examine improvements in depressive symptoms, and secondary outcomes, by specific sub-populations to determine who might do better in which treatment (i.e., BA or yoga). Given that this is the first non-inferior, comparative effectiveness study of yoga, this paper explains the study design, the rationale for the study design, as well as lessons learned in conducting the study.
AB - Depression is a prevalent mental health condition in the United States and a significant cause of morbidity and mortality. The treatment guidelines for depression recommends either psychotherapy, such as behavioral activation (BA), or a second-generation antidepressant as a first-line treatment for adult patients with depression. However, many individuals with depression do not experience improvement from first-line treatments or choose not to engage in them due to stigma, cost, difficulty with access, and/or side effects. As such we need new treatments for depression and yoga is especially promising given recent data on its efficacy for depression. This study seeks to compare a first-line treatment for depression, or BA, versus yoga to examine whether yoga does as well as BA at improving depressive symptoms and secondary outcomes. We will also examine improvements in depressive symptoms, and secondary outcomes, by specific sub-populations to determine who might do better in which treatment (i.e., BA or yoga). Given that this is the first non-inferior, comparative effectiveness study of yoga, this paper explains the study design, the rationale for the study design, as well as lessons learned in conducting the study.
UR - https://www.scopus.com/pages/publications/85214364400
UR - https://www.scopus.com/inward/citedby.url?scp=85214364400&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0315506
DO - 10.1371/journal.pone.0315506
M3 - Article
C2 - 39761255
AN - SCOPUS:85214364400
SN - 1932-6203
VL - 20
JO - PloS one
JF - PloS one
IS - 1 January
M1 - e0315506
ER -