Expanded safety and efficacy data for a new Method of performing Electroconvulsive therapy focal electrically administered seizure therapy

Gregory L. Sahlem, E. Baron Short, Suzanne Kerns, Jon Snipes, William Devries, James B. Fox, Carol Burns, Matthew Schmidt, Ziad H. Nahas, Mark S. George, Harold A. Sackeim

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objective: Electroconvulsive therapy (ECT) is the most rapid and effective antidepressant treatment but with concerns about cognitive adverse effects. A new form of ECT, focal electrically administered seizure therapy (FEAST), was designed to increase the focality of stimulation and better match stimulus parameters with neurophysiology. We recently reported on the safety and feasibility of FEAST in a cohort (n = 17) of depressed patients. We now report on the safety, feasibility, preliminary efficacy, and cognitive effects of FEAST in a new cohort. Methods: Open-label FEASTwas administered to 20 depressed adults (6 men; 3 with bipolar disorder; age 49.1 ± 10.6 years). Clinical and cognitive assessments were obtained at baseline and end of course. Time to orientation recovery was assessed at each treatment. Nonresponders switched to conventional ECT. Results: Participants tolerated the treatment well with no dropouts. Five patients (25%) transitioned from FEAST to conventional ECT due to inadequate response. After FEAST (mean, 9.3 ± 3.5 sessions; range, 4-14), therewas a 58.1%± 36.0% improvement in Hamilton Rating Scale for Depression scores compared with that in the baseline (P < 0.0001); 13 (65%) of 20 patients met response criteria, and 11 (55%) of 20 met remission criteria. Patients achieved reorientation (4 of 5 items) in 4.4 ± 3.0 minutes (median, 4.5 minutes), timed from eyes opening. There was no deterioration in neuropsychological measures. Conclusions: These findings provide further support for the safety and efficacy of FEAST. The remission and response rateswere in the range found using conventional ECT, and the time to reorientation may be quicker. However, without a randomized comparison group, conclusions are tentative.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalJournal of ECT
Issue number3
StatePublished - Aug 23 2016

Bibliographical note

Publisher Copyright:
© Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.


  • Cognitive adverse effects
  • Depression
  • Ect
  • Efficacy
  • Electroconvulsive therapy


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