Expanded nuclear roles for IkappaBs.

Paul W. Bates, Shigeki Miyamoto

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

I kappa B (IkappaB) was initially identified as a factor that inhibits DNA binding and nuclear translocation of the transcription factor nuclear factor kappa B (NF-kappaB). Recently, however, IkappaB family members have demonstrated direct nuclear roles in regulating NF-kappaB-dependent transcription. Some IkappaB proteins, including IkappaBalpha and IkappaBbeta, can regulate transcription by modulating the concentration of active NF-kappaB complexes within the nucleus. Others, such as IkappaBzeta and Bcl-3, can directly activate transcription by forming transcriptional complexes at gene promoters. Thus, IkappaB proteins play important nuclear roles in regulating NF-kappaB-dependent transcription after stimulation with various extracellular signals.

Original languageEnglish (US)
Pages (from-to)pe48
JournalScience's STKE : signal transduction knowledge environment
Volume2004
Issue number254
StatePublished - Oct 12 2004

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