Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes

Keyphrases

• Novel mutation 100%
• Exome Sequencing 100%
• UV mutagenesis 100%
• Trichostatin A 100%
• Mutation Signature 100%
• Primary Keratinocytes 100%
• Ultraviolet Radiation 100%
• UV-B Radiation 50%
• Skin Cancer 33%
• Ultraviolet-B (UV-B) 33%
• Histone Deacetylase Inhibitor (HDACi) 16%
• Cancer Development 16%
• DNA Damage 16%
• Keratinocytes 16%
• Whole Exome Sequencing 16%
• Multiple Genes 16%
• DNA Elements 16%
• Recurring 16%
• Mutagens 16%
• Sequence Specificity 16%
• Sequence Motif 16%
• Chromatin Condensation 16%
• Direct Sequencing 16%
• Mutation Type 16%
• Mutation Spectrum 16%
• Skin Tumorigenesis 16%
• Driver mutations 16%
• Radiation Condition 16%
• DNA mutagenesis 16%
• Founding mutation 16%
• KCNJ12 16%
• TRIOBP 16%
• Ultraviolet-induced 16%
• Number of mutations 16%
• Mutation Profile 16%
• Single nucleotide Substitution 16%
• Mutation Hotspot 16%

Biochemistry, Genetics and Molecular Biology

• Exome Sequencing 100%
• Ultraviolet Radiation 100%
• Trichostatin A 100%
• Keratinocyte 100%
• Mutagenesis 33%
• Chromatin 33%
• DNA Damage 33%
• Sequence Motif 33%
• KCNJ12 33%
• Carcinogenesis 33%
• Histone Deacetylase 33%
• Nucleotide 33%