Exogenous surfactant and partial liquid ventilation: Physiologic and pathologic effects

J. P. Mrozek, K. M. Smith, D. R. Bing, P. A. Meyers, S. C. Simonton, J. E. Connet, M. C. Mammel

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We compared the effects of surfactant and partial liquid ventilation (PLV), and the impact of administration order, on oxygenation, respiratory system compliance (Crs), hemodynamics, and lung pathology in an animal lung injury model. We studied four groups: surfactant alone (S; n = 8); partial liquid ventilation alone (PLV-only; n = 8); surfactant followed by partial liquid ventilation (S-PLV; n = 8); and partial liquid ventilation followed by surfactant (PLV-S; n = 8). Following treatments, all animals had improved oxygenation index (Ol) and Crs. Animals in PLV groups showed continued improvement over 2 h (% change Ol: PLV-S -83% versus S -47%, p < 0.05; % change Crs: S-PLV 73% versus S 13%, p < 0.05). We also saw administration-order effects: surfactant before PLV improved Crs (0.92 ml/cm H2O after surfactant versus 1.13 ml/cm H2O after PLV, p < 0.02) without changing Ol, whereas surfactant after PLV did not change Crs and Ol increased (5.01 after PLV versus 8.92 after surfactant, p < 0.03). Hemodynamics were not different between groups. Pathologic analysis demonstrated decreased lung injury in dependent lobes of all PLV-treated animals, and in all lobes of S-PLV animals, when compared with the lobes of the S animals (p < 0.05). We conclude that surfactant therapy in combination with PLV improved oxygenation, respiratory system mechanics, and lung pathology to a greater degree than surfactant therapy alone. Administration order affected initial physiologic response and ultimate pathology: surfactant given before PLV produced the greatest improvements in pathologic outcomes.

Original languageEnglish (US)
Pages (from-to)1058-1065
Number of pages8
JournalAmerican journal of respiratory and critical care medicine
Issue number4 PART I
StatePublished - 1997


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