Background:A hormonal aetiology is one explanation for the lower incidence of myeloid leukaemia in women compared with men.Methods:In this population-based case-control study, we evaluated associations between exogenous hormone use and reproductive history and myeloid leukaemia, overall and by disease subtype.Results:We observed a suggestive association between oral contraceptive use and acute myeloid leukaemia (odds ratio=0.55, 95% confidence interval=0.32-0.96). Hormone replacement therapy and reproductive factors were not associated with risk.Conclusion:Despite the biological plausibility for a role of oestrogen in leukaemogenesis, other aetiologic factors are likely to explain the differing incidence rates in males and females.
Bibliographical noteFunding Information:
This study was supported by NIH R01 CA107143 (to JAR), K05 CA157439 (to JAR), and R25 CA047888 (to CKB).
- hormone replacement therapy
- myeloid leukaemia
- oral contraceptives