Exercise training reduces myocardial lipid peroxidation following short- term ischemia-reperfusion

Haydar A. Demirel, Scott K. Powers, Corinne Caillaud, Jeff S. Coombes, Hisashi Naito, Louise A. Fletcher, Iannis Vrabas, James V. Jessup, Li L. Ji

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Purpose: The purpose of these experiments was to test the hypothesis that endurance exercise training will reduce myocardial lipid peroxidation following short-term ischemia and reperfusion (I-R). Methods: Female Sprague- Dawley rats (4 months old) were randomly assigned to either a sedentary control group (N = 13) or to an exercise training group (N = 13). The exercise trained animals ran 4 d · wk-1 (90 min · d-1) at ~75% of V̇2(max). Following a 10-wk training program, animals were anesthetized, mechanically ventilated, and the chest was opened by thoracotomy. Coronary occlusion was achieved by a ligature around the left coronary artery; occlusion was maintained for 5 min followed by a 10-min period of reperfusion. Results: Although training did not alter (P > 0.05) myocardial activities of antioxidant enzymes (superoxide dismutase and glutathione peroxidase), training was associated with significant increases (P < 0.05) in heat shock protein (HSP72) in the left ventricle. Compared with controls, trained animals exhibited significantly lower levels (P < 0.05) of myocardial lipid peroxidation following I-R. Conclusions: These data support the hypothesis that exercise training provides protection against myocardial lipid peroxidation induced by short-term I-R in vivo.

Original languageEnglish (US)
Pages (from-to)1211-1216
Number of pages6
JournalMedicine and science in sports and exercise
Issue number8
StatePublished - Aug 1998


  • Cardiac hypertrophy
  • Endurance exercise
  • Free radicals
  • Heart
  • Heat shock proteins


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