Exercise Training Improves Heart Rate Variability in Older Patients With Heart Failure: A Randomized, Controlled, Single-Blinded Trial

Khalil Murad, Peter H. Brubaker, David M. Fitzgerald, Timothy M. Morgan, David C. Goff, Elsayed Z. Soliman, Joel D. Eggebeen, Dalane W. Kitzman

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Reduced heart rate variability (HRV) in older patients with heart failure (HF) is common and indicates poor prognosis. Exercise training (ET) has been shown to improve HRV in younger patients with HF. However, the effect of ET on HRV in older patients with HF is not known. Sixty-six participants (36% men), aged 69±5years, with HF and both preserved ejection fraction (HFPEF) and reduced ejection fraction (HFREF), were randomly assigned to 16weeks of supervised ET (ET group) vs attention-control (AC group). Two HRV parameters (the standard deviation of all normal RR intervals [SDNN] and the root mean square of successive differences in normal RR intervals [RMSSD]) were measured at baseline and after completion of the study. When compared with the AC group, the ET group had a significantly greater increase in both SDNN (15.46±5.02ms in ET vs 2.37±2.13ms in AC, P=016) and RMSSD (17.53±7.83ms in ET vs 1.69±2.63ms in AC, P=003). This increase was seen in both sexes and HF categories. ET improved HRV in older patients with both HFREF and HFPEF.

Original languageEnglish (US)
Pages (from-to)192-197
Number of pages6
JournalCongestive Heart Failure
Volume18
Issue number4
DOIs
StatePublished - 2012

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