Exercise reduces persistent ductus arteriosus shunting in piglets

David Seaberg, Elizabeth Lorenz, Gunnar Lund, Joseph Rysavy, Mary Ella Pierpont, Shu Lun Zhang, Stanley Einzig

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Summary: To determine the effects of dynamic exercise on ductal left to right shunting and skeletal and myocardial blood flow distribution, a persistent ductus arteriosus was created by balloon catheters in neonatal piglets. At 8-10 weeks of age, aortic, pulmonary artery, and left atrial catheters were placed and radiolabelled microspheres injected for measuring left ventricular output, organ blood flows, and ductus left to right shunting at rest and during treadmill exercise (1.6 mph). At rest, effective left ventricular output and myocardial and skeletal muscle blood flows were similar in the study group and controls. Exercise increased skeletal muscle and left ventricular blood flows similarly in the control and study group and did not accentuate the exercise induced small reduction in the left ventricular subendocardial to subepicardial blood flow ratio. This was due to a significant reduction in the ductus left to right shunt during exercise (mean(SD) 34(15) vs 18(7)%, p<0.02) and maintenance of effective left ventricular output in the study group (447(144) vs 446(98) ml·min-1·kg-1 in controls). The reduction in ductus shunting during exercise was due to a significant decrease in systemic vascular resistance and a small increase in pulmonary vascular and ductus resistance. Thus, reduced persistent ductus arteriosus shunting and maintenance of effective left ventricular output prevents myocardial perfusion abnormalities during dynamic exercise in swine with a persistent ductus and small to moderate left to right shunts.

Original languageEnglish (US)
Pages (from-to)847-855
Number of pages9
JournalCardiovascular Research
Volume21
Issue number11
DOIs
StatePublished - Nov 1987

Keywords

  • Echocardiography
  • Exercise
  • Myocardial blood flow
  • Persistent ductus arteriosus
  • Radioactive microspheres
  • Skeletal muscle blood flow

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