Exercise is medicine in cystic fibrosis

Courtney M. Wheatley, Brad W. Wilkins, Eric M. Snyder

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Exercise activates adrenergic and purinergic pathways that regulate activity of ion channels on airway epithelia cells and sweat glands. Therefore, we hypothesize that exercise is not only an important therapy for cystic fibrosis (CF) patients by facilitating systemic improvements but, more importantly, that exercise can improve the pathophysiological ion dysregulation at a cellular level, thereby enhancing quality of life in CF.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalExercise and Sport Sciences Reviews
Volume39
Issue number3
DOIs
StatePublished - Jul 1 2011

Keywords

  • ADBR2
  • CFTR
  • ENaC
  • P2Y2
  • airway surface liquid
  • sweat gland
  • thermoregulation

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