Exercise Intolerance in Facioscapulohumeral Muscular Dystrophy

VERA, K. A., M. MCCONVILLE, A. GLAZOS, W. STOKES, M. KYBA, and M. KELLER-ROSS. Exercise Intolerance in FacioscapulohumeralMuscular Dystrophy. Med. Sci. Sports Exerc., Vol. 54, No. 6, pp. 887-895, 2022. Purpose: Determine 1) if adults with facioscapulohumeral muscular dystrophy (FSHD) exhibit exercise intolerance and 2) potential contributing mechanisms to exercise intolerance, specific to FSHD. Methods: Eleven people with FSHD (47 ± 13 yr, 4 females) and 11 controls (46 ± 13 yr, 4 females) completed one visit, which included a volitional peak oxygen consumption (V˙O_2peak) cycling test. Breath-by-breath gas exchange, ventilation, and cardiovascular responses were measured at rest and during exercise. The test featured 3-min stages (speed, 65-70 rpm)with incremental increases in intensity (FSHD: 20Wper stage; control: 40-60Wper stage). Body lean mass (LM (kg, %)) was collected via dual-energy x-ray absorptiometry. Results: V˙O_2peak was 32% lower (24.5 ± 9.7 vs 36.2 ± 9.3 mL·kg^-1·min^-1, P < 0.01), and wattage was 55% lower in FSHD (112.7 ± 56.1 vs 252.7 ± 67.7 W, P < 0.01). When working at a relative submaximal intensity (40% of V˙O_2peak), wattage was 55% lower in FSHD (41.8 ± 30.3 vs 92.7 ± 32.6 W, P = 0.01), although ratings of perceived exertion (FSHD: 11 ± 2 vs control: 10 ± 3, P = 0.61) and dyspnea (FSHD: 3 ± 1 vs control: 3 ± 2, P = 0.78) were similar between groups. At an absolute intensity (60W), the rating of perceived exertion was 63% higher (13 ± 3 vs 8 ± 2, P < 0.01) and dyspnea was 180% higher in FSHD (4 ± 2 vs 2 ± 2, P < 0.01). V˙O_2peak was most strongly correlated with resting O₂ pulse in controls (P < 0.01, r = 0.90) and percent leg LM in FSHD (P < 0.01, r = 0.88). Among FSHD participants, V˙O_2peak was associated with self-reported functionality (FSHD-HI score; activity limitation: P < 0.01, r = -0.78), indicating a strong association between perceived and objective impairments. Conclusions:Disease-driven losses of LMcontribute to exercise intolerance in FSHD, as evidenced by a lower V˙O_2peak and elevated symptoms of dyspnea and fatigue during submaximal exercise. Regular exercise participation may preserve LM, thus providing some protection against exercise tolerance in FSHD.