Exercise-induced hormesis may help healthy aging

Li Li Ji, Jonathan R. Dickman, Chounghun Kang, Ryan Koenig

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α activated mitochondrial biogenesis, and eccentric contraction-induced, cytokine-propelled muscle inflammation could be important redox-sensitive pathways by which exercise-induced disturbance in oxidant-antioxidant hemeostasis may serve as a heretic stimulus to promote adaptations that help healthy aging and improve the quality of life.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
Issue number1
StatePublished - 2010
Externally publishedYes


  • Aging
  • Exercise
  • Hormesis
  • Muscle
  • Reactive oxygen species


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