Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adults

Donald R. Dengel, Michael D. Brown, Robert E. Ferrell, Thomas H. Reynolds IV, Mark A. Supiano

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26 Scopus citations

Abstract

We evaluated the association between insulin resistance and the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism in a group of older hypertensive subjects (63 ± 1 yr, n = 35) before and after a 6-mo aerobic exercise program (AEX). Insulin sensitivity index (SI), assessed by the frequently sampled intravenous glucose tolerance test, was significantly (P = 0.0001) increased following AEX. In addition, there was a significant (P = 0.001) interaction between AEX and ACE genotype. SI increased significantly (P < 0.05) more in those with the II (2.5 ± 0.8 μU × 10-4 · min -1 · ml-1) ACE genotype compared with both the DD and ID (0.7 ± 0.1 and 0.7 ± 0.2 μU × 10-4 · min-1 · ml-1, respectively) ACE genotypes. Similarly, there was a significant (P = 0.036) decrease in the acute insulin response to glucose (AIRG) and a significant (P = 0.05) interaction between AEX and ACE genotype. AIRG decreased significantly (P < 0.05) more in those with the II (-17.6 ± 5.6 mU/ml) ACE genotype compared with both the DD and ID (-1.4 ± 6.2 and -3.6 ± 2.5 mU/ml) ACE genotypes. In conclusion, we demonstrated that those older hypertensives with the ACE II genotype have the greatest improvement in insulin action following AEX.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalPhysiological genomics
Volume11
DOIs
StatePublished - Jan 2003

Keywords

  • Angiotensin-converting enzyme
  • Blood pressure
  • Genetics
  • Glucose metabolism

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