Exercise and hormesis: Activation of cellular antioxidant signaling pathway

Li Li Ji, Maria Carmen Gomez-Cabrera, Jose Vina

Research output: Contribution to journalArticlepeer-review

336 Scopus citations


Contraction-induced production of reactive oxygen species (ROS) has been shown to cause oxidative stress to skeletal muscle. As an adaptive response, muscle antioxidant defense systems are upregulated after heavy exercise. Nuclear factor (NF) κB and mitogen-activated protein kinases (MAPKs) are the major oxidative stress-sensitive signal transduction pathways in mammalian tissues. Activation of NF-κB signaling cascade has been shown to enhance the gene expression of important enzymes, such as mitochondrial superoxide dismutase (MnSOD) and inducible nitric oxide synthase (iNOS). MAPK activations are involved in a variety of cellular functions including growth, proliferation, and adaptation. We investigated the effect of an acute bout of exercise on NF-κB and MAPK signaling, as well as on the time course of activation, in rat skeletal muscle. In addition, we studied the role of ROS in the exercise-induced upregulation of MnSOD and iNOS, and the potential interactions of NF-κB and MAPK in the signaling of these enzymes. Our data suggest that ROS may serve as messenger molecules to activate adaptive responses through these redox-sensitive signaling pathways to maintain cellular oxidant-antioxidant homeostasis during exercise.

Original languageEnglish (US)
Pages (from-to)425-435
Number of pages11
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - May 2006


  • Antioxidant
  • Exercise
  • MAPK
  • Nuclear factor (NF) kappa B
  • Reactive oxygen species


Dive into the research topics of 'Exercise and hormesis: Activation of cellular antioxidant signaling pathway'. Together they form a unique fingerprint.

Cite this