Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord

Linda M. Aanonsen, Sizheng Lei, George L. Wilcox

Research output: Contribution to journalArticlepeer-review

236 Scopus citations

Abstract

Excitatory amino acid (EAA) receptor agonists were tested for their effect on identified rat spinal neurons. Only 75% of the spinal neurons tested increased their firing rate in response to iontophoretic application of one or more of the EAA receptor agonists, N-methyl-d-aspartate (NMDA), quisqualate (Quis), (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid HBr (AMPA), and kainate (KA). NMDA and Quis or AMPA activated primarily nociceptive neurons (60% of these neurons were projection neurons) in the rat spinal cord. KA-activated neurons were primarily classified as low threshold neurons. Both NMDA and AMPA, at subthreshold doses, significantly increased neuronal responses to peripheral noxious mechanical stimulation; NMDA also significantly increased neuronal responses to peripheral noxious thermal stimulation. Iontophoretically applied phencyclidine (PCP) decreased NMDA-induced firing in 100% of the cells tested while Quis-induced firing was blocked by PCP in only 33% of the cells tested. The reported analgesic effects of PCP in humans may result from a spinal action involving its well documented interaction with NMDA receptors.

Original languageEnglish (US)
Pages (from-to)309-321
Number of pages13
JournalPain
Volume41
Issue number3
DOIs
StatePublished - Jun 1990

Bibliographical note

Funding Information:
We wish to thank Ms. Georgeta Poliac for techpdca! ,,ssistance. This work was supported by NIDA Grants 01933 and 04274.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Excitatory amino acids
  • Glutamate
  • N-methyl-d-aspartate
  • Nociception
  • Phencyclidine
  • Quisqualate
  • Spinal neurons

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