Excitation-Contraction Uncoupling: Major Role in Contraction-Induced Muscle Injury

Gordon L. Warren; Christopher P. Ingalls; Dawn A. Lowe; R. B. Armstrong

doi:10.1097/00003677-200104000-00008

Excitation-Contraction Uncoupling: Major Role in Contraction-Induced Muscle Injury

Gordon L. Warren, Christopher P. Ingalls, Dawn A. Lowe, R. B. Armstrong

Physical Therapy

Research output: Contribution to journal › Article › peer-review

224 Scopus citations

Abstract

The mechanisms that account for the strength loss after contraction-induced muscle injury remain controversial. We present data showing that (1) most of the early strength loss results from a failure of excitation-contraction coupling and (2) a slow loss of contractile protein in the days after injury prolongs the recovery time.

Original language	English (US)
Pages (from-to)	82-87
Number of pages	6
Journal	Exercise and sport sciences reviews
Volume	29
Issue number	2
DOIs	https://doi.org/10.1097/00003677-200104000-00008
State	Published - Apr 2001

Keywords

Calcium
Contractile protein
Damage
Plasmalemma
Sarcoplasmic reticulum
Strength

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10.1097/00003677-200104000-00008

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title = "Excitation-Contraction Uncoupling: Major Role in Contraction-Induced Muscle Injury",

abstract = "The mechanisms that account for the strength loss after contraction-induced muscle injury remain controversial. We present data showing that (1) most of the early strength loss results from a failure of excitation-contraction coupling and (2) a slow loss of contractile protein in the days after injury prolongs the recovery time.",

keywords = "Calcium, Contractile protein, Damage, Plasmalemma, Sarcoplasmic reticulum, Strength",

author = "Warren, {Gordon L.} and Ingalls, {Christopher P.} and Lowe, {Dawn A.} and Armstrong, {R. B.}",

year = "2001",

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T2 - Major Role in Contraction-Induced Muscle Injury

AU - Warren, Gordon L.

AU - Ingalls, Christopher P.

AU - Lowe, Dawn A.

AU - Armstrong, R. B.

PY - 2001/4

Y1 - 2001/4

N2 - The mechanisms that account for the strength loss after contraction-induced muscle injury remain controversial. We present data showing that (1) most of the early strength loss results from a failure of excitation-contraction coupling and (2) a slow loss of contractile protein in the days after injury prolongs the recovery time.

AB - The mechanisms that account for the strength loss after contraction-induced muscle injury remain controversial. We present data showing that (1) most of the early strength loss results from a failure of excitation-contraction coupling and (2) a slow loss of contractile protein in the days after injury prolongs the recovery time.

KW - Calcium

KW - Contractile protein

KW - Damage

KW - Plasmalemma

KW - Sarcoplasmic reticulum

KW - Strength

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JO - Exercise and sport sciences reviews

JF - Exercise and sport sciences reviews

IS - 2

ER -

Excitation-Contraction Uncoupling: Major Role in Contraction-Induced Muscle Injury

Abstract

Keywords

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