Excitation-Contraction Uncoupling: Major Role in Contraction-Induced Muscle Injury

Gordon L. Warren, Christopher P. Ingalls, Dawn A. Lowe, R. B. Armstrong

Research output: Contribution to journalArticlepeer-review

224 Scopus citations


The mechanisms that account for the strength loss after contraction-induced muscle injury remain controversial. We present data showing that (1) most of the early strength loss results from a failure of excitation-contraction coupling and (2) a slow loss of contractile protein in the days after injury prolongs the recovery time.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalExercise and sport sciences reviews
Issue number2
StatePublished - Apr 2001


  • Calcium
  • Contractile protein
  • Damage
  • Plasmalemma
  • Sarcoplasmic reticulum
  • Strength


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