Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice

Manohar B. Mutnal, Maxim C Cheeran, Shuxian Hu, Morgan R. Little, James R Lokensgard

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared to wild-type animals. Enhanced microglial cell activation, determined by MHC class II up-regulation, overexpression of CXCL2, and elevated P-selectin mRNA levels were observed. In vivo blocking of CXCL2 attenuated neutrophil infiltration and significantly improved the outcome of infection. Collectively, these data indicate that the absence of IL-10 results in pathologic neutrophil infiltration into MCMV-infected brains.

Original languageEnglish (US)
Pages (from-to)101-110
Number of pages10
JournalJournal of Neuroimmunology
Volume227
Issue number1-2
DOIs
StatePublished - Oct 1 2010

Keywords

  • CXCL2
  • IL-10
  • Microglia
  • Neutrophil

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