Excess BMI in childhood: A modifiable risk factor for type 1 diabetes development?

Christine Therese Ferrara; Susan Michelle Geyer; Yuk Fun Liu; Carmella Evans-Molina; Ingrid M. Libman; Rachel Besser; Dorothy J. Becker; Henry Rodriguez; Antoinette Moran; Stephen E. Gitelman; Maria J. Redondo

doi:10.2337/dc16-2331

Excess BMI in childhood: A modifiable risk factor for type 1 diabetes development?

Christine Therese Ferrara, Susan Michelle Geyer, Yuk Fun Liu, Carmella Evans-Molina, Ingrid M. Libman, Rachel Besser, Dorothy J. Becker, Henry Rodriguez, Antoinette Moran, Stephen E. Gitelman, Maria J. Redondo

Pediatric Endocrinology

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS: Westudied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibodypositive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sexand age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS: Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS: Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.

Original language	English (US)
Pages (from-to)	698-701
Number of pages	4
Journal	Diabetes care
Volume	40
Issue number	5
DOIs	https://doi.org/10.2337/dc16-2331
State	Published - May 1 2017

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Publisher Copyright:
© 2017 by the American Diabetes Association.

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10.2337/dc16-2331

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399656

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title = "Excess BMI in childhood: A modifiable risk factor for type 1 diabetes development?",

abstract = "OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS: Westudied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibodypositive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sexand age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS: Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS: Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.",

author = "Ferrara, {Christine Therese} and Geyer, {Susan Michelle} and Liu, {Yuk Fun} and Carmella Evans-Molina and Libman, {Ingrid M.} and Rachel Besser and Becker, {Dorothy J.} and Henry Rodriguez and Antoinette Moran and Gitelman, {Stephen E.} and Redondo, {Maria J.}",

note = "Publisher Copyright: {\textcopyright} 2017 by the American Diabetes Association.",

year = "2017",

month = may,

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doi = "10.2337/dc16-2331",

language = "English (US)",

volume = "40",

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TY - JOUR

T1 - Excess BMI in childhood

T2 - A modifiable risk factor for type 1 diabetes development?

AU - Ferrara, Christine Therese

AU - Geyer, Susan Michelle

AU - Liu, Yuk Fun

AU - Evans-Molina, Carmella

AU - Libman, Ingrid M.

AU - Besser, Rachel

AU - Becker, Dorothy J.

AU - Rodriguez, Henry

AU - Moran, Antoinette

AU - Gitelman, Stephen E.

AU - Redondo, Maria J.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS: Westudied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibodypositive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sexand age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS: Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS: Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.

AB - OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS: Westudied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibodypositive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sexand age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS: Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS: Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.

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JO - Diabetes care

JF - Diabetes care

IS - 5

ER -

Excess BMI in childhood: A modifiable risk factor for type 1 diabetes development?

Abstract

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UN SDGs

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