Exceptionally Elastic Single-Component Pharmaceutical Crystals

Kunlin Wang, Manish Kumar Mishra, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We report here the first elastically bendable single-component pharmaceutical crystal, celecoxib. Interlocked molecular packing without the slip plane and the presence of an isotropic hydrogen bond network are major structural features responsible for both the exceptional elastic flexibility and high stiffness of the celecoxib crystal as revealed by bending and nanomechanical studies. The molecular model of the exceptional elasticity is rationalized by the inhomogeneous spatial separations of molecules in the bent crystal, which is further confirmed by micro-Raman spectroscopy. The celecoxib crystal, exhibiting both therapeutic effects and elastic mechanical behavior, could be used to manufacture functional microdevices with novel medical applications.

Original languageEnglish (US)
Pages (from-to)1794-1799
Number of pages6
JournalChemistry of Materials
Volume31
Issue number5
DOIs
StatePublished - Mar 12 2019

Bibliographical note

Funding Information:
The authors acknowledge the Minnesota Supercomputing Institute (MSI) at the University of Minnesota for providing resources that contributed to the research results reported within this paper. URL: http://www.msi.umn.edu. Parts of this work were carried out in the Characterization Facility, University of Minnesota, which receives partial support from NSF through the MRSEC program. K.W. also thanks the Edward G. Rippie Fellowship and David Grant Fellowship of the University of Minnesota Department of Pharmaceutics for partial financial support.

Publisher Copyright:
© 2019 American Chemical Society.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Fingerprint

Dive into the research topics of 'Exceptionally Elastic Single-Component Pharmaceutical Crystals'. Together they form a unique fingerprint.

Cite this