Examples Showing the Utility of Doping Experiments in 1H NMR Analysis of Mixtures

Trinadh Kaicharla, Bhavani Shankar Chinta, Thomas R. Hoye

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Here we provide examples that demonstrate the value of using properly designed and easily performed doping experiments to give insights about the nature of the analyte(s) present in a 1H NMR sample. Two mixtures, the first quite complex and the second far less so, have been chosen: (i) the crude pyrolysate from reaction of butyric acid in (supercritical) water at 600 °C and (ii) a mixture of two basic amines. In the former, 13 distinct carbonyl-containing compounds, ranging in relative concentration of nearly 2 orders of magnitude, were positively identified. The latter highlights the advantage of using a doping experiment as opposed to merely comparing the spectra from two separate samples containing the same analyte.

Original languageEnglish (US)
Pages (from-to)5660-5667
Number of pages8
JournalJournal of Organic Chemistry
Volume87
Issue number9
DOIs
StatePublished - May 6 2022

Bibliographical note

Funding Information:
This investigation was supported by a grant from the National Science Foundation (CHE-1665389) and a subaward from the SarTec Corporation by way of a grant from the Department of Energy and its Office of Biotechnology (DE-SC0018792).

Publisher Copyright:
© 2022 American Chemical Society.

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