Examples Showing the Utility of Doping Experiments in 1H NMR Analysis of Mixtures

Trinadh Kaicharla, Bhavani Shankar Chinta, Thomas R. Hoye

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Here we provide examples that demonstrate the value of using properly designed and easily performed doping experiments to give insights about the nature of the analyte(s) present in a 1H NMR sample. Two mixtures, the first quite complex and the second far less so, have been chosen: (i) the crude pyrolysate from reaction of butyric acid in (supercritical) water at 600 °C and (ii) a mixture of two basic amines. In the former, 13 distinct carbonyl-containing compounds, ranging in relative concentration of nearly 2 orders of magnitude, were positively identified. The latter highlights the advantage of using a doping experiment as opposed to merely comparing the spectra from two separate samples containing the same analyte.

Original languageEnglish (US)
Pages (from-to)5660-5667
Number of pages8
JournalJournal of Organic Chemistry
Issue number9
StatePublished - May 6 2022

Bibliographical note

Funding Information:
This investigation was supported by a grant from the National Science Foundation (CHE-1665389) and a subaward from the SarTec Corporation by way of a grant from the Department of Energy and its Office of Biotechnology (DE-SC0018792).

Publisher Copyright:
© 2022 American Chemical Society.


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