Evolving Strategies to Potentially Further Optimize Surgical Interventions in Brain Cancer

Bindi B. Parikh, Elizabeth C. Neil

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


PURPOSE OF REVIEW: Provide an overview, the indications for use, and a synopsis of current literature regarding two evolving neurosurgical interventions-GammaTile therapy (GTT) and laser interstitial thermal therapy (LITT).

RECENT FINDINGS: GTT delivers immediate, uniform, high-dose radiation with avoidance of direct brain-to-seed contact. Innate properties of the novel carrier system and cesium-131 source may explain lower observed rate of radiation-induced necrosis (RIN) and support use in larger and previously irradiated lesions. LITT delivers focal laser energy to cause heat-generated necrosis. Case series suggest use in difficult-to-access lesions and treatment of RIN. Collaboration among subspecialties and remaining up-to-date on evolving technology is critical in developing individualized treatment plans for patients with brain cancer. While patients should be thoroughly counseled that these interventions are not standard of care, in optimal clinical scenarios, GTT and LITT could extend quantity and quality of life for patients with few remaining options. Prospective studies are needed to establish specific treatment parameters.

Original languageEnglish (US)
Article number32
JournalCurrent oncology reports
Issue number4
StatePublished - Mar 6 2020

Bibliographical note

Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.


  • Brachytherapy
  • GammaTile
  • Glioblastoma
  • Laser interstitial thermal therapy
  • Metastatic brain cancer
  • Primary brain cancer

PubMed: MeSH publication types

  • Journal Article
  • Review


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