Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes

Stephen S. Hecht, Pramod Upadhyaya, Mingyao Wang

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

This perspective reviews our work on the identification of DNA adducts of N-nitrosopyrrolidine and some related aldehydes. The research began as a focused project to investigate mechanisms of cyclic nitrosamine carcinogenesis but expanded into other areas, as aldehyde metabolites of NPYR were shown to have their own diverse DNA adduct chemistry. A total of 69 structurally distinct DNA adducts were identified, and some of these, found in human tissues, have provided intriguing leads for investigating carcinogenesis mechanisms in humans due to exposure to both endogenous and exogenous agents.

Original languageEnglish (US)
Pages (from-to)781-790
Number of pages10
JournalChemical research in toxicology
Volume24
Issue number6
DOIs
StatePublished - Jun 20 2011

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