Evolution of DNA and RNA as catalysts for chemical reactions

Andres Jäschke, Burckhard Seelig

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


In vitro selection from combinatorial nucleic acid libraries has provided new RNA and DNA molecules that have catalytic properties. Catalyzed reactions now go far beyond self-modifying reactions of nucleic acid molecules. The future application of in vitro selected RNA and DNA catalysts in bioorganic synthesis appears promising.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalCurrent opinion in chemical biology
Issue number3
StatePublished - Jun 1 2000

Bibliographical note

Funding Information:
Work in the author’s laboratory is supported by the Deutsche Forschungsgemeinschaft (DFG) and by the Bundesministerium für Bildung und Forschung (BMBF).

Copyright 2017 Elsevier B.V., All rights reserved.


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