Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome

Hyun Don Yun; Marie Lue Antony; Michael A. Linden; Klara E. Noble-Orcutt; Craig E. Eckfeldt; Celalettin Ustun; Andrew C. Nelson; Zohar Sachs

doi:10.1016/j.leukres.2020.106404

Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome

Hyun Don Yun, Marie Lue Antony, Michael A. Linden, Klara E. Noble-Orcutt, Craig E. Eckfeldt, Celalettin Ustun, Andrew C. Nelson, Zohar Sachs

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Original language	English (US)
Article number	106404
Journal	Leukemia research
Volume	95
DOIs	https://doi.org/10.1016/j.leukres.2020.106404
State	Published - Aug 2020

Bibliographical note

Funding Information:
The authors would like to thank the staff of the M Health-Fairview Molecular Diagnostics Laboratory for processing NGS samples. This work utilized the resources of the Flow Cytometry Resource and other services of the Masonic Cancer Center (which is supported by NIHP30 CA77598) at the University of Minnesota. This work and Z.S. were supported by the American Cancer Society, Frederick A. DeLuca Foundation, Mentored Research Scholar Grant (MRSG-16-195-01-DDC); the Clinical and Translational Science Institute at the University of Minnesota KL2 Career Development Award NIH/NCATS ULI RR033183 & KL2 RR0333182; the University of Minnesota Department of Medicine Women's Early Research Career Award; the division of Hematology, Oncology, and Transplantation, Department of Medicine; and the University of Minnesota Foundation donors. HDY is supported by Hematology T32 Research Training Grant (5T32 HL007062-42, NIH). ACN is supported by the American Cancer Society, Clinical Scientist Development Grant, CSDG-18-139-01-CSM.

Funding Information:
The authors would like to thank the staff of the M Health-Fairview Molecular Diagnostics Laboratory for processing NGS samples. This work utilized the resources of the Flow Cytometry Resource and other services of the Masonic Cancer Center (which is supported by NIH P30 CA77598) at the University of Minnesota. This work and Z.S. were supported by the American Cancer Society, F rederick A. DeLuca Foundation, M entored Research Scholar Grant ( MRSG-16-195-01-DDC ); the Clinical and Translational Science Institute at the University of Minnesota KL2 Career Development Award NIH/NCATS ULI RR033183 & KL2 RR0333182; the University of Minnesota Department of Medicine Women’s Early Research Career Award ; the division of Hematology, Oncology, and Transplantation, Department of Medicine ; and the University of Minnesota Foundation donors . HDY is supported by Hematology T32 Research Training Grant ( 5T32 HL007062-42 , NIH). ACN is supported by the American Cancer Society, Clinical Scientist Development Grant , CSDG-18-139-01-CSM .

PubMed: MeSH publication types

Case Reports
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2020.106404

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@article{1858f3bd7a584413b128097888fd2c72,

title = "Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome",

author = "Yun, {Hyun Don} and Antony, {Marie Lue} and Linden, {Michael A.} and Noble-Orcutt, {Klara E.} and Eckfeldt, {Craig E.} and Celalettin Ustun and Nelson, {Andrew C.} and Zohar Sachs",

note = "Funding Information: The authors would like to thank the staff of the M Health-Fairview Molecular Diagnostics Laboratory for processing NGS samples. This work utilized the resources of the Flow Cytometry Resource and other services of the Masonic Cancer Center (which is supported by NIHP30 CA77598) at the University of Minnesota. This work and Z.S. were supported by the American Cancer Society, Frederick A. DeLuca Foundation, Mentored Research Scholar Grant (MRSG-16-195-01-DDC); the Clinical and Translational Science Institute at the University of Minnesota KL2 Career Development Award NIH/NCATS ULI RR033183 & KL2 RR0333182; the University of Minnesota Department of Medicine Women's Early Research Career Award; the division of Hematology, Oncology, and Transplantation, Department of Medicine; and the University of Minnesota Foundation donors. HDY is supported by Hematology T32 Research Training Grant (5T32 HL007062-42, NIH). ACN is supported by the American Cancer Society, Clinical Scientist Development Grant, CSDG-18-139-01-CSM. Funding Information: The authors would like to thank the staff of the M Health-Fairview Molecular Diagnostics Laboratory for processing NGS samples. This work utilized the resources of the Flow Cytometry Resource and other services of the Masonic Cancer Center (which is supported by NIH P30 CA77598) at the University of Minnesota. This work and Z.S. were supported by the American Cancer Society, F rederick A. DeLuca Foundation, M entored Research Scholar Grant ( MRSG-16-195-01-DDC ); the Clinical and Translational Science Institute at the University of Minnesota KL2 Career Development Award NIH/NCATS ULI RR033183 & KL2 RR0333182; the University of Minnesota Department of Medicine Women{\textquoteright}s Early Research Career Award ; the division of Hematology, Oncology, and Transplantation, Department of Medicine ; and the University of Minnesota Foundation donors . HDY is supported by Hematology T32 Research Training Grant ( 5T32 HL007062-42 , NIH). ACN is supported by the American Cancer Society, Clinical Scientist Development Grant , CSDG-18-139-01-CSM . ",

year = "2020",

month = aug,

doi = "10.1016/j.leukres.2020.106404",

language = "English (US)",

volume = "95",

journal = "Leukemia research",

issn = "0145-2126",

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T1 - Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome

AU - Yun, Hyun Don

AU - Antony, Marie Lue

AU - Linden, Michael A.

AU - Noble-Orcutt, Klara E.

AU - Eckfeldt, Craig E.

AU - Ustun, Celalettin

AU - Nelson, Andrew C.

AU - Sachs, Zohar

N1 - Funding Information: The authors would like to thank the staff of the M Health-Fairview Molecular Diagnostics Laboratory for processing NGS samples. This work utilized the resources of the Flow Cytometry Resource and other services of the Masonic Cancer Center (which is supported by NIHP30 CA77598) at the University of Minnesota. This work and Z.S. were supported by the American Cancer Society, Frederick A. DeLuca Foundation, Mentored Research Scholar Grant (MRSG-16-195-01-DDC); the Clinical and Translational Science Institute at the University of Minnesota KL2 Career Development Award NIH/NCATS ULI RR033183 & KL2 RR0333182; the University of Minnesota Department of Medicine Women's Early Research Career Award; the division of Hematology, Oncology, and Transplantation, Department of Medicine; and the University of Minnesota Foundation donors. HDY is supported by Hematology T32 Research Training Grant (5T32 HL007062-42, NIH). ACN is supported by the American Cancer Society, Clinical Scientist Development Grant, CSDG-18-139-01-CSM. Funding Information: The authors would like to thank the staff of the M Health-Fairview Molecular Diagnostics Laboratory for processing NGS samples. This work utilized the resources of the Flow Cytometry Resource and other services of the Masonic Cancer Center (which is supported by NIH P30 CA77598) at the University of Minnesota. This work and Z.S. were supported by the American Cancer Society, F rederick A. DeLuca Foundation, M entored Research Scholar Grant ( MRSG-16-195-01-DDC ); the Clinical and Translational Science Institute at the University of Minnesota KL2 Career Development Award NIH/NCATS ULI RR033183 & KL2 RR0333182; the University of Minnesota Department of Medicine Women’s Early Research Career Award ; the division of Hematology, Oncology, and Transplantation, Department of Medicine ; and the University of Minnesota Foundation donors . HDY is supported by Hematology T32 Research Training Grant ( 5T32 HL007062-42 , NIH). ACN is supported by the American Cancer Society, Clinical Scientist Development Grant , CSDG-18-139-01-CSM .

PY - 2020/8

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Evolution of clonal dynamics and differential response to targeted therapy in a case of systemic mastocytosis with associated myelodysplastic syndrome

Bibliographical note

PubMed: MeSH publication types

UN SDGs

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