Evolution of β-cell replacement therapy in diabetes mellitus: Pancreas transplantation

Cyrus Jahansouz, Sean C. Kumer, Michael Ellenbogen, Kenneth L. Brayman

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Diabetes mellitus remains one of the leading causes of morbidity and mortality worldwide. According to the Centers for Disease Control and Prevention, approximately 23.6 million people in the United States are affected. Of these individuals, 5-10% have been diagnosed with type 1 diabetes mellitus (TIDM), an autoimmune disease. Although it often appears in childhood, T1DM may manifest at any age. The effects of T1DM can be devastating, as the disease often leads to significant secondary complications, morbidity, and decreased quality of life. Since the late 1960s, surgical treatment for diabetes mellitus has continued to evolve and has become a viable alternative to chronic insulin administration. In this review, the historical evolution, current status, graft efficacy, benefits, and complications of pancreas transplantation are explored.

Original languageEnglish (US)
Pages (from-to)395-418
Number of pages24
JournalDiabetes Technology and Therapeutics
Issue number3
StatePublished - Mar 1 2011
Externally publishedYes


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