Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains

Chun Ming Lin, Linda J. Saif, Douglas Marthaler, Qiuhong Wang

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations


Emerging and re-emerging coronaviruses cause morbidity and mortality in human and animal populations, resulting in serious public and animal health threats and economic losses. The ongoing outbreak of a highly contagious and deadly porcine epidemic diarrhea virus (PEDV) in Asia, the Americas and Europe is one example. Genomic sequence analyses of PEDV variants have revealed important insights into the evolution of PEDV. However, the antigenic variations among different PEDV strains are less explored, although they may contribute to the failure of PEDV vaccines in Asian countries. In addition, the evolution of PEDV results in variants with distinct genetic features and virulence differences; thus PEDV can serve as a model to explore the molecular mechanisms of coronavirus evolution and pathogenesis. In this article, we review the evolution, antigenic relationships and pathologic features of PEDV strains. This information and review of researches will aid in the development of strategies for control and prevention of PED.

Original languageEnglish (US)
Pages (from-to)20-39
Number of pages20
JournalVirus research
StatePublished - Dec 2 2016

Bibliographical note

Funding Information:
Our studies on PEDV were funded by Novartis Animal Health US, Inc. (QW, PI; LJS, co-PI), National Pork Board (Grant # 14-265 , QW, PI; LJS, co-PI), USDA (Grant # 2015-67015-23067 , QW, PI; LJS, co-PI), OARDC / OSU Seeds # 2015-008 (QW, PI), and Merck/Intervet (QW, PI; LJS, co-PI). Salaries and research support were provided by state and federal funds appropriated to OARDC , The Ohio State University . The authors would like to acknowledge Dr. Anastasia Vlasova at The Ohio State Univeristy, Drs. Li Feng and Jianfei Chen at Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, and Dr. Dongbo Sun at College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, for their helpful discussions, Dr. Min-Yuan Chia at Department of Veterinary Medicine, National Chung Hsing University, Taiwan, for the consultations on antigenic map preparation. We appreciate Dr. Lanlan Zheng, Mr. Yixuan Hou, and Mr. Yibin Qin for their technical assistance and Ms. Susan Sommer-Wagner for editing assistance.

Publisher Copyright:
© 2016 Elsevier B.V.


  • Antigenicity
  • Coronavirus
  • Cross-protection
  • Cross-reactivity
  • Evolution
  • Pathogenicity
  • Porcine epidemic diarrhea
  • Porcine epidemic diarrhea virus


Dive into the research topics of 'Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains'. Together they form a unique fingerprint.

Cite this