Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains

Chun Ming Lin; Linda J. Saif; Douglas Marthaler; Qiuhong Wang

doi:10.1016/j.virusres.2016.05.023

Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains

Chun Ming Lin, Linda J. Saif, Douglas Marthaler, Qiuhong Wang

Veterinary Population Medicine

Research output: Contribution to journal › Review article › peer-review

119 Scopus citations

Abstract

Emerging and re-emerging coronaviruses cause morbidity and mortality in human and animal populations, resulting in serious public and animal health threats and economic losses. The ongoing outbreak of a highly contagious and deadly porcine epidemic diarrhea virus (PEDV) in Asia, the Americas and Europe is one example. Genomic sequence analyses of PEDV variants have revealed important insights into the evolution of PEDV. However, the antigenic variations among different PEDV strains are less explored, although they may contribute to the failure of PEDV vaccines in Asian countries. In addition, the evolution of PEDV results in variants with distinct genetic features and virulence differences; thus PEDV can serve as a model to explore the molecular mechanisms of coronavirus evolution and pathogenesis. In this article, we review the evolution, antigenic relationships and pathologic features of PEDV strains. This information and review of researches will aid in the development of strategies for control and prevention of PED.

Original language	English (US)
Pages (from-to)	20-39
Number of pages	20
Journal	Virus research
Volume	226
DOIs	https://doi.org/10.1016/j.virusres.2016.05.023
State	Published - Dec 2 2016

Bibliographical note

Funding Information:
Our studies on PEDV were funded by Novartis Animal Health US, Inc. (QW, PI; LJS, co-PI), National Pork Board (Grant # 14-265 , QW, PI; LJS, co-PI), USDA (Grant # 2015-67015-23067 , QW, PI; LJS, co-PI), OARDC / OSU Seeds # 2015-008 (QW, PI), and Merck/Intervet (QW, PI; LJS, co-PI). Salaries and research support were provided by state and federal funds appropriated to OARDC , The Ohio State University . The authors would like to acknowledge Dr. Anastasia Vlasova at The Ohio State Univeristy, Drs. Li Feng and Jianfei Chen at Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, and Dr. Dongbo Sun at College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, for their helpful discussions, Dr. Min-Yuan Chia at Department of Veterinary Medicine, National Chung Hsing University, Taiwan, for the consultations on antigenic map preparation. We appreciate Dr. Lanlan Zheng, Mr. Yixuan Hou, and Mr. Yibin Qin for their technical assistance and Ms. Susan Sommer-Wagner for editing assistance.

Publisher Copyright:
© 2016 Elsevier B.V.

Keywords

Antigenicity
Coronavirus
Cross-protection
Cross-reactivity
Evolution
Pathogenicity
Porcine epidemic diarrhea
Porcine epidemic diarrhea virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.virusres.2016.05.023

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title = "Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains",

abstract = "Emerging and re-emerging coronaviruses cause morbidity and mortality in human and animal populations, resulting in serious public and animal health threats and economic losses. The ongoing outbreak of a highly contagious and deadly porcine epidemic diarrhea virus (PEDV) in Asia, the Americas and Europe is one example. Genomic sequence analyses of PEDV variants have revealed important insights into the evolution of PEDV. However, the antigenic variations among different PEDV strains are less explored, although they may contribute to the failure of PEDV vaccines in Asian countries. In addition, the evolution of PEDV results in variants with distinct genetic features and virulence differences; thus PEDV can serve as a model to explore the molecular mechanisms of coronavirus evolution and pathogenesis. In this article, we review the evolution, antigenic relationships and pathologic features of PEDV strains. This information and review of researches will aid in the development of strategies for control and prevention of PED.",

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author = "Lin, {Chun Ming} and Saif, {Linda J.} and Douglas Marthaler and Qiuhong Wang",

note = "Funding Information: Our studies on PEDV were funded by Novartis Animal Health US, Inc. (QW, PI; LJS, co-PI), National Pork Board (Grant # 14-265 , QW, PI; LJS, co-PI), USDA (Grant # 2015-67015-23067 , QW, PI; LJS, co-PI), OARDC / OSU Seeds # 2015-008 (QW, PI), and Merck/Intervet (QW, PI; LJS, co-PI). Salaries and research support were provided by state and federal funds appropriated to OARDC , The Ohio State University . The authors would like to acknowledge Dr. Anastasia Vlasova at The Ohio State Univeristy, Drs. Li Feng and Jianfei Chen at Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, and Dr. Dongbo Sun at College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, for their helpful discussions, Dr. Min-Yuan Chia at Department of Veterinary Medicine, National Chung Hsing University, Taiwan, for the consultations on antigenic map preparation. We appreciate Dr. Lanlan Zheng, Mr. Yixuan Hou, and Mr. Yibin Qin for their technical assistance and Ms. Susan Sommer-Wagner for editing assistance. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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doi = "10.1016/j.virusres.2016.05.023",

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AU - Lin, Chun Ming

AU - Saif, Linda J.

AU - Marthaler, Douglas

AU - Wang, Qiuhong

N1 - Funding Information: Our studies on PEDV were funded by Novartis Animal Health US, Inc. (QW, PI; LJS, co-PI), National Pork Board (Grant # 14-265 , QW, PI; LJS, co-PI), USDA (Grant # 2015-67015-23067 , QW, PI; LJS, co-PI), OARDC / OSU Seeds # 2015-008 (QW, PI), and Merck/Intervet (QW, PI; LJS, co-PI). Salaries and research support were provided by state and federal funds appropriated to OARDC , The Ohio State University . The authors would like to acknowledge Dr. Anastasia Vlasova at The Ohio State Univeristy, Drs. Li Feng and Jianfei Chen at Division of Swine Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China, and Dr. Dongbo Sun at College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, for their helpful discussions, Dr. Min-Yuan Chia at Department of Veterinary Medicine, National Chung Hsing University, Taiwan, for the consultations on antigenic map preparation. We appreciate Dr. Lanlan Zheng, Mr. Yixuan Hou, and Mr. Yibin Qin for their technical assistance and Ms. Susan Sommer-Wagner for editing assistance. Publisher Copyright: © 2016 Elsevier B.V.

PY - 2016/12/2

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N2 - Emerging and re-emerging coronaviruses cause morbidity and mortality in human and animal populations, resulting in serious public and animal health threats and economic losses. The ongoing outbreak of a highly contagious and deadly porcine epidemic diarrhea virus (PEDV) in Asia, the Americas and Europe is one example. Genomic sequence analyses of PEDV variants have revealed important insights into the evolution of PEDV. However, the antigenic variations among different PEDV strains are less explored, although they may contribute to the failure of PEDV vaccines in Asian countries. In addition, the evolution of PEDV results in variants with distinct genetic features and virulence differences; thus PEDV can serve as a model to explore the molecular mechanisms of coronavirus evolution and pathogenesis. In this article, we review the evolution, antigenic relationships and pathologic features of PEDV strains. This information and review of researches will aid in the development of strategies for control and prevention of PED.

AB - Emerging and re-emerging coronaviruses cause morbidity and mortality in human and animal populations, resulting in serious public and animal health threats and economic losses. The ongoing outbreak of a highly contagious and deadly porcine epidemic diarrhea virus (PEDV) in Asia, the Americas and Europe is one example. Genomic sequence analyses of PEDV variants have revealed important insights into the evolution of PEDV. However, the antigenic variations among different PEDV strains are less explored, although they may contribute to the failure of PEDV vaccines in Asian countries. In addition, the evolution of PEDV results in variants with distinct genetic features and virulence differences; thus PEDV can serve as a model to explore the molecular mechanisms of coronavirus evolution and pathogenesis. In this article, we review the evolution, antigenic relationships and pathologic features of PEDV strains. This information and review of researches will aid in the development of strategies for control and prevention of PED.

KW - Antigenicity

KW - Coronavirus

KW - Cross-protection

KW - Cross-reactivity

KW - Evolution

KW - Pathogenicity

KW - Porcine epidemic diarrhea

KW - Porcine epidemic diarrhea virus

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DO - 10.1016/j.virusres.2016.05.023

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AN - SCOPUS:84993990211

VL - 226

SP - 20

EP - 39

JO - Virus Research

JF - Virus Research

SN - 0168-1702

ER -

Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains

Abstract

Bibliographical note

Keywords

UN SDGs

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