Evidence that the peroxidase of the fatty acid cyclooxygenase acts via a fenton type of reaction

D. A. Peterson; J. M. Gerrard

doi:10.1016/0262-1746(83)90069-0

Evidence that the peroxidase of the fatty acid cyclooxygenase acts via a fenton type of reaction

D. A. Peterson
, J. M. Gerrard

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Addition of ferrous sulfate to a solution containing peroxy-methyl arachidonate resulted in cleavage of the peroxy group on the methyl arachidonate as assessed by absorption at 232nm. The results suggest that ferrous iron can be involved in the reduction of fatty acid peroxides and supports the possibility that the peroxidase component of the fatty acid cyclooxygenase occurs via a Fenton type reaction.

Original language	English (US)
Pages (from-to)	73-76
Number of pages	4
Journal	Prostaglandins Leukotrienes and Medicine
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/0262-1746(83)90069-0
State	Published - Sep 1983

Bibliographical note

Funding Information:
We gratefully acknowledge the support of grant MA-7396 from the Medical Research Council of Canada and USPHS grant AM12466 to Dr. S. Schwartz. Jonathan M. Gerrard is the recipient of a Canadian MRC scholarship.

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title = "Evidence that the peroxidase of the fatty acid cyclooxygenase acts via a fenton type of reaction",

abstract = "Addition of ferrous sulfate to a solution containing peroxy-methyl arachidonate resulted in cleavage of the peroxy group on the methyl arachidonate as assessed by absorption at 232nm. The results suggest that ferrous iron can be involved in the reduction of fatty acid peroxides and supports the possibility that the peroxidase component of the fatty acid cyclooxygenase occurs via a Fenton type reaction.",

author = "Peterson, \{D. A.\} and Gerrard, \{J. M.\}",

note = "Funding Information: We gratefully acknowledge the support of grant MA-7396 from the Medical Research Council of Canada and USPHS grant AM12466 to Dr. S. Schwartz. Jonathan M. Gerrard is the recipient of a Canadian MRC scholarship.",

year = "1983",

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T1 - Evidence that the peroxidase of the fatty acid cyclooxygenase acts via a fenton type of reaction

AU - Peterson, D. A.

AU - Gerrard, J. M.

N1 - Funding Information: We gratefully acknowledge the support of grant MA-7396 from the Medical Research Council of Canada and USPHS grant AM12466 to Dr. S. Schwartz. Jonathan M. Gerrard is the recipient of a Canadian MRC scholarship.

PY - 1983/9

Y1 - 1983/9

N2 - Addition of ferrous sulfate to a solution containing peroxy-methyl arachidonate resulted in cleavage of the peroxy group on the methyl arachidonate as assessed by absorption at 232nm. The results suggest that ferrous iron can be involved in the reduction of fatty acid peroxides and supports the possibility that the peroxidase component of the fatty acid cyclooxygenase occurs via a Fenton type reaction.

AB - Addition of ferrous sulfate to a solution containing peroxy-methyl arachidonate resulted in cleavage of the peroxy group on the methyl arachidonate as assessed by absorption at 232nm. The results suggest that ferrous iron can be involved in the reduction of fatty acid peroxides and supports the possibility that the peroxidase component of the fatty acid cyclooxygenase occurs via a Fenton type reaction.

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UR - https://www.scopus.com/pages/publications/0020601209#tab=citedBy

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DO - 10.1016/0262-1746(83)90069-0

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JO - Prostaglandins Leukotrienes and Medicine

JF - Prostaglandins Leukotrienes and Medicine

IS - 1

ER -

Evidence that the peroxidase of the fatty acid cyclooxygenase acts via a fenton type of reaction

Abstract

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