Evidence that the peroxidase of the fatty acid cyclooxygenase acts via a fenton type of reaction

D. A. Peterson, J. M. Gerrard

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Addition of ferrous sulfate to a solution containing peroxy-methyl arachidonate resulted in cleavage of the peroxy group on the methyl arachidonate as assessed by absorption at 232nm. The results suggest that ferrous iron can be involved in the reduction of fatty acid peroxides and supports the possibility that the peroxidase component of the fatty acid cyclooxygenase occurs via a Fenton type reaction.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalProstaglandins, Leukotrienes and Medicine
Volume12
Issue number1
DOIs
StatePublished - Sep 1983

Bibliographical note

Funding Information:
We gratefully acknowledge the support of grant MA-7396 from the Medical Research Council of Canada and USPHS grant AM12466 to Dr. S. Schwartz. Jonathan M. Gerrard is the recipient of a Canadian MRC scholarship.

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