Addition of ferrous sulfate to a solution containing peroxy-methyl arachidonate resulted in cleavage of the peroxy group on the methyl arachidonate as assessed by absorption at 232nm. The results suggest that ferrous iron can be involved in the reduction of fatty acid peroxides and supports the possibility that the peroxidase component of the fatty acid cyclooxygenase occurs via a Fenton type reaction.
Bibliographical noteFunding Information:
We gratefully acknowledge the support of grant MA-7396 from the Medical Research Council of Canada and USPHS grant AM12466 to Dr. S. Schwartz. Jonathan M. Gerrard is the recipient of a Canadian MRC scholarship.