Evidence of direct nociceptive projections from the spinal cord to the hypothalamus and telencephalon

Glenn J. Giesler

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Many nociceptive neurons in the spinal cord of rats project directly to the hypothalamus. The axons of these neurons cross into the contralateral spinal cord and ascend through the posterior thalamus before entering the contralateral hypothalamus. The majority of these axons decussate again in the posterior optic chiasm, enter the ipsilateral hypothalamus, turn posteriorly and descend into the ipsilateral thalamus, midbrain, and in some cases, pens and even medulla before terminating. A smaller number of spinal neurons project directly to several telencephalic areas including the amygdala, nucleus accumbens, septal nuclei and the frontal cortex. Each of these direct projections to the hypothalamus and telencephalon may contribute to nociception.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalSeminars in the Neurosciences
Issue number4
StatePublished - 1995

Bibliographical note

Funding Information:
I am grateful to Drs R Burstein, KD Cliffer, RJ Dado and JT Katter, E Kostarczyk and X Zhang who participated in many of the studies described here. This work was supported by NS25932.

Copyright 2017 Elsevier B.V., All rights reserved.


  • Hypothalamus
  • Limbic system
  • Nociception
  • Pain
  • Spinal cord


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