Evidence for the replication of bovine leukemia virus in the B lymphocytes.

P. S. Paul; K. A. Pomeroy; D. W. Johnson; C. C. Muscoplat; B. S. Handwerger; F. F. Soper; D. K. Sorensen

Evidence for the replication of bovine leukemia virus in the B lymphocytes.

P. S. Paul
, K. A. Pomeroy
, D. W. Johnson
, C. C. Muscoplat
, B. S. Handwerger
, F. F. Soper
, D. K. Sorensen

Administration (CFANS)

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64 Scopus citations

Abstract

Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5% of the non-B cells.

Original language	English (US)
Pages (from-to)	873-876
Number of pages	4
Journal	American journal of veterinary research
Volume	38
Issue number	6
State	Published - Jun 1 1977

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@article{115e8f8d54a84f44a93e499e2bc0ac33,

title = "Evidence for the replication of bovine leukemia virus in the B lymphocytes.",

abstract = "Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5\%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3\%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39\% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5\% of the non-B cells.",

author = "Paul, \{P. S.\} and Pomeroy, \{K. A.\} and Johnson, \{D. W.\} and Muscoplat, \{C. C.\} and Handwerger, \{B. S.\} and Soper, \{F. F.\} and Sorensen, \{D. K.\}",

year = "1977",

month = jun,

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language = "English (US)",

volume = "38",

pages = "873--876",

journal = "American journal of veterinary research",

issn = "0002-9645",

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}

TY - JOUR

T1 - Evidence for the replication of bovine leukemia virus in the B lymphocytes.

AU - Paul, P. S.

AU - Pomeroy, K. A.

AU - Johnson, D. W.

AU - Muscoplat, C. C.

AU - Handwerger, B. S.

AU - Soper, F. F.

AU - Sorensen, D. K.

PY - 1977/6/1

Y1 - 1977/6/1

N2 - Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5% of the non-B cells.

AB - Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5% of the non-B cells.

UR - https://www.scopus.com/pages/publications/0017503912

UR - https://www.scopus.com/pages/publications/0017503912#tab=citedBy

M3 - Article

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AN - SCOPUS:0017503912

SN - 0002-9645

VL - 38

SP - 873

EP - 876

JO - American journal of veterinary research

JF - American journal of veterinary research

IS - 6

ER -

Evidence for the replication of bovine leukemia virus in the B lymphocytes.

Abstract

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