Evidence for the replication of bovine leukemia virus in the B lymphocytes.

P. S. Paul, K. A. Pomeroy, D. W. Johnson, C. C. Muscoplat, B. S. Handwerger, F. F. Soper, D. K. Sorensen

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60 Scopus citations


Bovine peripheral blood lymphocytes from a cow with persistent lymphocytosis were separated on nylon wool columns into nylon-adherent and nonadherent populations. Nylon-adherent cells were highly enriched for surface immunoglobulin (SIg) bearing B lymphocytes (95.5%) and nonadherent cells for SIg negative non-B cells, presumably T lymphocytes (96.3%). The B lymphocytes were found to be the major producers for bovine leukemia virus. A total of 39% of the B-enriched cells, surviving after 72 hours in culture, produced bovine leukemia virus as compared with 0.5% of the non-B cells.

Original languageEnglish (US)
Pages (from-to)873-876
Number of pages4
JournalAmerican journal of veterinary research
Issue number6
StatePublished - Jun 1 1977


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