Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia

Patricia L. Faris; Barry R. Komisaruk; Linda R. Watkins; David J. Mayer

doi:10.1126/science.6294831

Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia

Patricia L. Faris, Barry R. Komisaruk, Linda R. Watkins, David J. Mayer

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

539 Scopus citations

Abstract

The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.

Original language	English (US)
Pages (from-to)	310-312
Number of pages	3
Journal	Science
Volume	219
Issue number	4582
DOIs	https://doi.org/10.1126/science.6294831
State	Published - Jan 1 1983

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title = "Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia",

abstract = "The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.",

author = "Faris, {Patricia L.} and Komisaruk, {Barry R.} and Watkins, {Linda R.} and Mayer, {David J.}",

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AU - Komisaruk, Barry R.

AU - Watkins, Linda R.

AU - Mayer, David J.

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N2 - The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.

AB - The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.

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Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia

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