Evidence for specificity of ERP abnormalities during response inhibition in ADHD children: A comparison with reading disorder children without ADHD

Mario Liotti, Steven R. Pliszka, Kellie Higgins, Ricardo Perez, Margaret Semrud-Clikeman

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Executive function and working memory deficits are not only present in ADHD, but also in reading disorder (RD). Here, high-density ERPs were recorded during the Stop Signal Task in 53 children and adolescents: An ADHD-combined type group, a group with RD, and a healthy control group. The ADHD-C group displayed unique abnormalities of the frontal N200. Both healthy controls and RD groups showed a success-related right frontal N200 modulation, which was absent in the ADHD group. Second, for Success Inhibition trials, the ADHD-C had smaller right frontal N200 waves relative to healthy controls, while the RD group did not. In contrast, NoGo-P3 abnormalities were present both in the ADHD-C and RD groups. Impaired early response inhibition mechanisms, indexed by the frontal N200, appear to be limited to ADHD-C. In contrast, deficits in later cognitive control and error monitoring mechanisms, indexed by the NoGo-P3, appear to be present in both conditions.

Original languageEnglish (US)
Pages (from-to)228-237
Number of pages10
JournalBrain and Cognition
Volume72
Issue number2
DOIs
StatePublished - Mar 2010

Bibliographical note

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

  • ADHD
  • Event-related potentials
  • Inhibitory control
  • N200
  • NoGo-P3
  • Reading disorder
  • Stop Signal Task

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