Evidence for population-specific positive selection on immune genes of anopheles gambiae

Jacob E. Crawford, Emmanuel Bischoff, Thierry Garnier, Awa Gneme, Karin Eiglmeier, Inge Holm, Michelle M. Riehle, Wamdaogo M. Guelbeogo, N'Fale Sagnon, Brian P. Lazzaro, Kenneth D. Vernick

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Host-pathogen interactions can be powerful drivers of adaptive evolution, shaping the patterns of molecular variation at the genes involved. In this study, we sequenced alleles from 28 immune-related loci in wild samples of multiple genetic subpopulations of the African malaria mosquito Anopheles gambiae, obtaining unprecedented sample sizes and providing the first opportunity to contrast patterns of molecular evolution at immune-related loci in the recently discovered GOUNDRY population to those of the indoor-resting M and S molecular forms. In contrast to previous studies that focused on immune genes identified in laboratory studies, we centered our analysis on genes that fall within a quantitative trait locus associated with resistance to Plasmodium falciparum in natural populations of A. gambiae. Analyses of haplotypic and genetic diversity at these 28 loci revealed striking differences among populations in levels of genetic diversity and allele frequencies in coding sequence. Putative signals of positive selection were identified at 11 loci, but only one was shared by two subgroups of A. gambiae. Striking patterns of linkage disequilibrium were observed at several loci. We discuss these results with respect to ecological differences among these strata as well as potential implications for disease transmission.

Original languageEnglish (US)
Pages (from-to)1505-1519
Number of pages15
JournalG3: Genes, Genomes, Genetics
Volume2
Issue number12
DOIs
StatePublished - Dec 2012

Keywords

  • Anopheles gambiae
  • Host-pathogen interaction
  • Immune gene
  • Plasmodium falciparum
  • Positive selection

Fingerprint Dive into the research topics of 'Evidence for population-specific positive selection on immune genes of anopheles gambiae'. Together they form a unique fingerprint.

  • Cite this

    Crawford, J. E., Bischoff, E., Garnier, T., Gneme, A., Eiglmeier, K., Holm, I., Riehle, M. M., Guelbeogo, W. M., Sagnon, NF., Lazzaro, B. P., & Vernick, K. D. (2012). Evidence for population-specific positive selection on immune genes of anopheles gambiae. G3: Genes, Genomes, Genetics, 2(12), 1505-1519. https://doi.org/10.1534/g3.112.004473