Evidence for neural progenitor cells in the human adult enteric nervous system

Gaetano Azan, Walter C. Low, Gwen Wendelschafer-Crabb, Sayeed Ikramuddin, William R. Kennedy

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Putative neural stem cells have been identified within the enteric nervous system (ENS) of adult rodents and cultured from human myenteric plexus. We conducted studies to identify neural stem cells or progenitor cells within the submucosa of adult human ENS. Jejunum tissue was removed from adult human subjects undergoing gastric bypass surgery. The tissue was immunostained, and confocal images of ganglia in the submucosal plexus were collected to identify protein gene product 9.5 (PGP 9.5) - immunoractive neurons and neuronal progenitor cells that coexpress PGP 9.5 and nestin. In addition to PGP-9.5-positive/nestin-negative neuronal cells within ganglia, we observed two other types of cells: (1) cells in which PGP 9.5 and nestin were co-localized, (2) cells negative for both PGP 9.5 and nestin. These observations suggest that the latter two types of cells are related to a progenitor cell population and are consistent with the concept that the submucosa of human adult ENS contains stem cells capable of maintenance and repair within the peripheral nervous system.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalCell and Tissue Research
Volume344
Issue number2
DOIs
StatePublished - May 2011

Bibliographical note

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Enteric nervous system
  • Human
  • Nestin
  • Neural crest
  • Neural progenitor cells
  • Protein gene product 9.5

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