Evidence for Eosinophil Degranulation in the Pathogenesis of Herpes Gestationis

Andrew J. Scheman, Maria D. Hordinsky, David W Groth, Gregory M. Vercellotti, Kristin M. Leiferman

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Herpes gestationis is a pregnancy-related bullous dermatosis of unknown origin with associated tissue and peripheral blood eosinophilia. In this report, eosinophil degranulation in herpes gestationis was studied, and the role that the eosinophil may have as an effector cell that induces tissue damage through deposition of toxic cationic proteins is discussed. Using indirect immunofluorescence with antibody to human eosinophil granule major basic protein, major basic protein was observed both within tissue eosinophils and deposited extracellularly outside eosinophils in the dermis of eight patients with herpes gestationis. Possible mechanisms whereby eosinophils might be activated to degranulate in herpes gestationis are reviewed.

Original languageEnglish (US)
Pages (from-to)1079-1083
Number of pages5
JournalArchives of Dermatology
Issue number8
StatePublished - Aug 1989


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