Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain

Beáta Búzás, Sari Izenwasser, Philip S. Portoghese, Brian M. Cox

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Opioid agonists selective for mu- or delta opioid receptors inhibit adenyl yl cyclase in membranes from rat caudate-putamen and nucleus accumbens. The presence of subtypes of delta opioid receptors has been suggested. In both brain regions we have found that the inhibition of adenylyl cyclase by DPDPE was more readily antagonized by 7-benzylidenenaltrexone (BNTX), than by naltriben. In contrast, the inhibitory effects of deltorphin-II and DSLET were more readily antagonized by naltriben, than by BNTX. neither naltriben nor BNTX significantly antagonized the effect of a mu selective agonist. These results suggest that inhibition of adenylyl cyclase in caudate-putamen and nucleus accumbens is regulated by two forms of delta-opioid receptor with ligand selectivities similar to those two forms proposed to mediate analgesic effect.

Original languageEnglish (US)
Pages (from-to)PL101-PL106
JournalLife Sciences
Issue number7
StatePublished - 1994

Bibliographical note

Funding Information:
We thank Drs. Anna Borsodi and G~za T6th for supplying tritiatedd eltorphinI I, and Dr. Frank Porreca for initial supplies of deltorphin-IIa nd naltriben.T he opinions and assertions contained herein reflect the private views of the authors and are not to be construed as offical or reflectingt he views of Uniformed Services University or the U.S. Departmento f Defense. Animals used in this study were acquired and cared for in accordance with the guidelines published in the NIH Guide for the care and use of LaboratoryA nimals (NIH Publication No. 85-23). This work was supported by a grant from the National Instituteo n Drug Abuse.


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