TY - JOUR
T1 - Evidence for a role of plasma membrane calcium pumps in neurodegenerative disease
T2 - Recent developments
AU - Strehler, Emanuel E.
AU - Thayer, Stanley A.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/1/10
Y1 - 2018/1/10
N2 - Plasma membrane Ca2+ ATPases (PMCAs) are a major system for calcium extrusion from all cells. Different PMCA isoforms and splice variants are involved in the precise temporal and spatial handling of Ca2+ signals and the re-establishment of resting Ca2+ levels in the nervous system. Lack or inappropriate expression of specific PMCAs leads to characteristic neuronal phenotypes, which may be reciprocally exacerbated by genetic predisposition through alleles in other genes that modify PMCA interactions, regulation, and function. PMCA dysfunction is often poorly compensated in neurons and may lead to changes in synaptic transmission, altered excitability and, with long-term calcium overload, eventual cell death. Decrease and functional decline of PMCAs are hallmarks of neurodegeneration during aging, and mutations in specific PMCAs are responsible for neuronal dysfunction and accelerated neurodegeneration in many sensory and cognitive diseases.
AB - Plasma membrane Ca2+ ATPases (PMCAs) are a major system for calcium extrusion from all cells. Different PMCA isoforms and splice variants are involved in the precise temporal and spatial handling of Ca2+ signals and the re-establishment of resting Ca2+ levels in the nervous system. Lack or inappropriate expression of specific PMCAs leads to characteristic neuronal phenotypes, which may be reciprocally exacerbated by genetic predisposition through alleles in other genes that modify PMCA interactions, regulation, and function. PMCA dysfunction is often poorly compensated in neurons and may lead to changes in synaptic transmission, altered excitability and, with long-term calcium overload, eventual cell death. Decrease and functional decline of PMCAs are hallmarks of neurodegeneration during aging, and mutations in specific PMCAs are responsible for neuronal dysfunction and accelerated neurodegeneration in many sensory and cognitive diseases.
KW - Calcium homeostasis
KW - Cerebellar ataxia
KW - Excitotoxicity
KW - Neurodegenerative disease
KW - Plasma membrane calcium ATPase
UR - http://www.scopus.com/inward/record.url?scp=85028303605&partnerID=8YFLogxK
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U2 - 10.1016/j.neulet.2017.08.035
DO - 10.1016/j.neulet.2017.08.035
M3 - Review article
C2 - 28827127
AN - SCOPUS:85028303605
SN - 0304-3940
VL - 663
SP - 39
EP - 47
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -