Evidence for a common component in kinetically distinct transport systems of Saccharomyces cerevisiae

Robert J Roon, Gail M. Meyer, Fred S. Larimore

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Abstract

Two lines of evidence suggest that amino acid transport systems and the methylamine/ammonia transport system of Saccharomyces cerevisiae may share a common component or components. 1. Mutant strains have been derived which are defective in transport activity for methylamine and for amino acids. A single pleiotropic mutation appears to be responsible for the observed reduction in the various transport activities. 2. Transport systems for amino acids and for methylamine are sensitive to a similar degree to inhibition by proton conducting uncouplers, ATPase inhibitors, and ionophores.

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalMGG Molecular & General Genetics
Volume158
Issue number2
DOIs
StatePublished - Jan 1 1977

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