Event-related potential evidence of dysfunction in automatic processing in abstinent alcoholics

George Realmuto, Henri Begleiter, John Odencrantz, Bernice Porjesz

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

The preattentive automatic processing of 63 alcoholics and 27 controls was evaluated with an auditory inattentive event-related oddball paradigm. We examined the mismatch negativity and the N2-P3 complex. Results showed significantly greater amplitude for N2, P3 and the N2-P3 complex for controls but no individual lead (Fz, Cz, Pz) differences by group. A group-by-lead interaction was found for N2 and for the N2-P3 complex. There were no significant latency differences between groups; however, a significant age-by-group interaction effect on latency was greatest at the Cz electrode. Results reflect a possible aberration of automatic processing in alcoholics because of a defect in the mnemonic template necessary to match with an infrequent deviant stimuli. We also found suggestive evidence of a relative weakness of frontal cortical organization in alcoholics. Future studies are suggested that would help clarify these differences in alcoholics.

Original languageEnglish (US)
Pages (from-to)594-601
Number of pages8
JournalBiological psychiatry
Volume33
Issue number8-9
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Auditory event-related potentials
  • alcoholics
  • automatic processing
  • frontal cortical deficit
  • mismatch negativity

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