Event-recurring multiband SWIFT functional MRI with 200-ms temporal resolution during deep brain stimulation and isoflurane-induced burst suppression in rat

Ekaterina Paasonen; Jaakko Paasonen; Lauri J Lehto; Tiina Pirttimäki; Hanne Laakso; Lin Wu; Jun Ma; Djaudat Idiyatullin; Heikki Tanila; Silvia Mangia; Shalom Michaeli; Olli Gröhn

doi:10.1002/mrm.29154

Event-recurring multiband SWIFT functional MRI with 200-ms temporal resolution during deep brain stimulation and isoflurane-induced burst suppression in rat

Ekaterina Paasonen, Jaakko Paasonen, Lauri J Lehto, Tiina Pirttimäki, Hanne Laakso, Lin Wu, Jun Ma, Djaudat Idiyatullin, Heikki Tanila, Silvia Mangia, Shalom Michaeli, Olli Gröhn

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Purpose: To develop a high temporal resolution functional MRI method for tracking repeating events in the brain. Methods: We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution. Results: The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution. Conclusion: The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.

Original language	English (US)
Pages (from-to)	2872-2884
Number of pages	13
Journal	Magnetic resonance in medicine
Volume	87
Issue number	6
DOIs	https://doi.org/10.1002/mrm.29154
State	Published - Jun 2022

Bibliographical note

Funding Information:
The authors are grateful to Dr. Sheng Sang for technical assistance during the experiments and to Dr. Antonietta Canna for the assistance with the SPM use.

Publisher Copyright:
© 2022 International Society for Magnetic Resonance in Medicine

Keywords

DBS
HRF
MB-SWIFT
MSN
fMRI
fast imaging

Center for Magnetic Resonance Research (CMRR) tags

BFC
NFMC
NM
P41

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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10.1002/mrm.29154

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Paasonen, E., Paasonen, J., Lehto, L. J., Pirttimäki, T., Laakso, H., Wu, L., Ma, J., Idiyatullin, D., Tanila, H., Mangia, S., Michaeli, S., & Gröhn, O. (2022). Event-recurring multiband SWIFT functional MRI with 200-ms temporal resolution during deep brain stimulation and isoflurane-induced burst suppression in rat. Magnetic resonance in medicine, 87(6), 2872-2884. https://doi.org/10.1002/mrm.29154

Paasonen, E, Paasonen, J, Lehto, LJ, Pirttimäki, T, Laakso, H, Wu, L, Ma, J, Idiyatullin, D, Tanila, H, Mangia, S , Michaeli, S & Gröhn, O 2022, 'Event-recurring multiband SWIFT functional MRI with 200-ms temporal resolution during deep brain stimulation and isoflurane-induced burst suppression in rat', Magnetic resonance in medicine, vol. 87, no. 6, pp. 2872-2884. https://doi.org/10.1002/mrm.29154

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abstract = "Purpose: To develop a high temporal resolution functional MRI method for tracking repeating events in the brain. Methods: We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution. Results: The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution. Conclusion: The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.",

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author = "Ekaterina Paasonen and Jaakko Paasonen and Lehto, {Lauri J} and Tiina Pirttim{\"a}ki and Hanne Laakso and Lin Wu and Jun Ma and Djaudat Idiyatullin and Heikki Tanila and Silvia Mangia and Shalom Michaeli and Olli Gr{\"o}hn",

note = "Funding Information: The authors are grateful to Dr. Sheng Sang for technical assistance during the experiments and to Dr. Antonietta Canna for the assistance with the SPM use. Publisher Copyright: {\textcopyright} 2022 International Society for Magnetic Resonance in Medicine",

year = "2022",

month = jun,

doi = "10.1002/mrm.29154",

language = "English (US)",

volume = "87",

pages = "2872--2884",

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AU - Paasonen, Ekaterina

AU - Paasonen, Jaakko

AU - Lehto, Lauri J

AU - Pirttimäki, Tiina

AU - Laakso, Hanne

AU - Wu, Lin

AU - Ma, Jun

AU - Idiyatullin, Djaudat

AU - Tanila, Heikki

AU - Mangia, Silvia

AU - Michaeli, Shalom

AU - Gröhn, Olli

N1 - Funding Information: The authors are grateful to Dr. Sheng Sang for technical assistance during the experiments and to Dr. Antonietta Canna for the assistance with the SPM use. Publisher Copyright: © 2022 International Society for Magnetic Resonance in Medicine

PY - 2022/6

Y1 - 2022/6

N2 - Purpose: To develop a high temporal resolution functional MRI method for tracking repeating events in the brain. Methods: We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution. Results: The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution. Conclusion: The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.

AB - Purpose: To develop a high temporal resolution functional MRI method for tracking repeating events in the brain. Methods: We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution. Results: The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution. Conclusion: The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.

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Event-recurring multiband SWIFT functional MRI with 200-ms temporal resolution during deep brain stimulation and isoflurane-induced burst suppression in rat

Abstract

Bibliographical note

Keywords

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PubMed: MeSH publication types

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