evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach

Dibyendu Dana; Shatarupa De; Pratikkumar Rathod; Anibal R. Davalos; Daniel A. Novoa; Suneeta Paroly; Viviana M. Torres; Nisar Afzal; Ravi S. Lankalapalli; Susan A. Rotenberg; Emmanuel J. Chang; Gopal Subramaniam; Sanjai Kumar

doi:10.1039/c4cc04037f

evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach

Dibyendu Dana
, Shatarupa De
, Pratikkumar Rathod
, Anibal R. Davalos
, Daniel A. Novoa
, Suneeta Paroly
, Viviana M. Torres
, Nisar Afzal
, Ravi S. Lankalapalli
, Susan A. Rotenberg
, Emmanuel J. Chang
, Gopal Subramaniam
, Sanjai Kumar

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.

Original language	English (US)
Pages (from-to)	10875-10878
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	74
DOIs	https://doi.org/10.1039/c4cc04037f
State	Published - Aug 18 2014

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SDG 3 Good Health and Well-being

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10.1039/c4cc04037f

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Dana, D., De, S., Rathod, P., Davalos, A. R., Novoa, D. A., Paroly, S., Torres, V. M., Afzal, N., Lankalapalli, R. S., Rotenberg, S. A., Chang, E. J., Subramaniam, G., & Kumar, S. (2014). evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach. Chemical Communications, 50(74), 10875-10878. https://doi.org/10.1039/c4cc04037f

Dana, D, De, S, Rathod, P, Davalos, AR, Novoa, DA, Paroly, S, Torres, VM, Afzal, N, Lankalapalli, RS, Rotenberg, SA, Chang, EJ, Subramaniam, G & Kumar, S 2014, 'evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach', Chemical Communications, vol. 50, no. 74, pp. 10875-10878. https://doi.org/10.1039/c4cc04037f

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title = "evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach",

abstract = "A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.",

author = "Dibyendu Dana and Shatarupa De and Pratikkumar Rathod and Davalos, \{Anibal R.\} and Novoa, \{Daniel A.\} and Suneeta Paroly and Torres, \{Viviana M.\} and Nisar Afzal and Lankalapalli, \{Ravi S.\} and Rotenberg, \{Susan A.\} and Chang, \{Emmanuel J.\} and Gopal Subramaniam and Sanjai Kumar",

year = "2014",

month = aug,

day = "18",

doi = "10.1039/c4cc04037f",

language = "English (US)",

volume = "50",

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AU - Dana, Dibyendu

AU - De, Shatarupa

AU - Rathod, Pratikkumar

AU - Davalos, Anibal R.

AU - Novoa, Daniel A.

AU - Paroly, Suneeta

AU - Torres, Viviana M.

AU - Afzal, Nisar

AU - Lankalapalli, Ravi S.

AU - Rotenberg, Susan A.

AU - Chang, Emmanuel J.

AU - Subramaniam, Gopal

AU - Kumar, Sanjai

PY - 2014/8/18

Y1 - 2014/8/18

N2 - A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.

AB - A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.

UR - https://www.scopus.com/pages/publications/84906330054

UR - https://www.scopus.com/pages/publications/84906330054#tab=citedBy

U2 - 10.1039/c4cc04037f

DO - 10.1039/c4cc04037f

M3 - Article

C2 - 25089379

AN - SCOPUS:84906330054

SN - 1359-7345

VL - 50

SP - 10875

EP - 10878

JO - Chemical Communications

JF - Chemical Communications

IS - 74

ER -

evelopment of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach

Abstract

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