Evaluation of Zoster Immune Plasma: Treatment of Cutaneous Disseminated Zoster in Immunocompromised Patients

K. E. Groth, J. McCullough, S. C. Marker, R. J. Howard, R. L. Simmons, J. S. Najarian, H. H. Balfour

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Zoster immune plasma (ZIP) was evaluated for treatment of cutaneous disseminated zoster in immunocompromised hosts. Twenty patients were studied: 13 were enrolled in a double-blind protocol, five received ZIP under an open protocol, and two were observed without receiving a transfusion. In the double-blind study, eight patients actually received ZIP; five were given plasma lacking varicella-zoster virus antibodies (control plasma). The clinical course of zoster in the group given ZIP was the same as that of patients given control plasma or no transfusions. Because ZIP did not alter the clinical course of zoster and because zoster patients produced high-antibody titers without ZIP, we concluded that ZIP is not useful for treatment of cutaneous disseminated zoster and should be reserved for prevention or modification of varicella in exposed, susceptible immunocompromised patients.

Original languageEnglish (US)
Pages (from-to)1877-1879
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Volume239
Issue number18
DOIs
StatePublished - May 5 1978

Fingerprint

Dive into the research topics of 'Evaluation of Zoster Immune Plasma: Treatment of Cutaneous Disseminated Zoster in Immunocompromised Patients'. Together they form a unique fingerprint.

Cite this