The Goldwyn-Watt model is a 4-element lumped parameter model for the vascular system used in order to estimate total arterial compliance non-invasively from a peripherally measured arterial pressure wave. We aim to evaluate the method's stability by making use of a distributed transmission line model, simulating different haemodynamic conditions. A mathematical transmission line model is used to compute the arterial pressure wave 44 cm downstream from the heart (brachial artery) at 55, 65 and 75 beats/minute, and at four levels of arterial compliance (0.86 to 3.45 ml/mm Hg), covering the physiological and pathological range. The Goldwyn-Watt model was used to derive the model parameters (compliance C1 and C2 and inertance L) from the computed pressure waves. We found the model parameters C1, C2 and L to vary with both heart rate and compliance level. The estimated total compliance differed more from the exactly known value with increasing heart rate and compliance level. We showed that C2 cannot be interpreted as the compliance of some distal part of the circulation. We conclude that the application of the Goldwyn-Watt model for the estimation of cardiovascular parameters from peripheral wave contour analysis is sensitive to the heart rate and the actual compliance of the arteries. The physical interpretation of C2 and L especially is not straightforward, and consequently neither is its diagnostic value.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Cardiovascular Diagnosis and Procedures|
|State||Published - Jan 1 1997|