Evaluation of the gastric retention properties of a cross-linked polymer coated tablet versus those of a non-disintegrating tablet

George A. Agyilirah; Mark Green; Rene duCret; Gilbert S. Banker

doi:10.1016/0378-5173(91)90198-W

Evaluation of the gastric retention properties of a cross-linked polymer coated tablet versus those of a non-disintegrating tablet

George A. Agyilirah, Mark Green, Rene duCret, Gilbert S. Banker

Radiology

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63 Scopus citations

Abstract

The gastric emptying time of tablets coated with a cross-linked polymer that enabled them to balloon and float in gastric media has been compared with that of uncoated, non-disintegrating tablets in both fasted and fed states, with healthy human volunteers using gamma camera scintigraphy. In the fed state, the balloon tablets prolonged the gastric emptying time by an average of 6 h over that of the uncoated tablets. The emptying times for both coated and uncoated tablets were much shorter in the fasting state. The balloon tablet did not significantly prolong the gastric emptying time in the fasted state.

Original language	English (US)
Pages (from-to)	241-247
Number of pages	7
Journal	International journal of pharmaceutics
Volume	75
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-5173(91)90198-W
State	Published - Sep 20 1991

Bibliographical note

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Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Coated tablet
Crosslinked polymer
Delayed gastric emptying
Fasted vs fed state
Gamma camera scintigraphy

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10.1016/0378-5173(91)90198-W

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AU - Banker, Gilbert S.

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N2 - The gastric emptying time of tablets coated with a cross-linked polymer that enabled them to balloon and float in gastric media has been compared with that of uncoated, non-disintegrating tablets in both fasted and fed states, with healthy human volunteers using gamma camera scintigraphy. In the fed state, the balloon tablets prolonged the gastric emptying time by an average of 6 h over that of the uncoated tablets. The emptying times for both coated and uncoated tablets were much shorter in the fasting state. The balloon tablet did not significantly prolong the gastric emptying time in the fasted state.

AB - The gastric emptying time of tablets coated with a cross-linked polymer that enabled them to balloon and float in gastric media has been compared with that of uncoated, non-disintegrating tablets in both fasted and fed states, with healthy human volunteers using gamma camera scintigraphy. In the fed state, the balloon tablets prolonged the gastric emptying time by an average of 6 h over that of the uncoated tablets. The emptying times for both coated and uncoated tablets were much shorter in the fasting state. The balloon tablet did not significantly prolong the gastric emptying time in the fasted state.

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KW - Delayed gastric emptying

KW - Fasted vs fed state

KW - Gamma camera scintigraphy

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Evaluation of the gastric retention properties of a cross-linked polymer coated tablet versus those of a non-disintegrating tablet

Abstract

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Keywords

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