Evaluation of risk factors for fatal acute pancreatitis in dogs

Rebecka S. Hess, Philip H. Kass, Frances S. Shofer, Thomas J. Van Winkle, Robert J. Washabau

Research output: Contribution to journalReview article

121 Citations (Scopus)

Abstract

Objective - To identify risk factors associated with fatal acute pancreatitis in dogs. Design - Case-control study. Animals - 70 case dogs with clinical evidence and histopathologic confirmation of fatal acute pancreatitis and 104 control dogs that had trauma, underwent necropsy, and did not have histologic evidence of acute pancreatitis. Procedure - Information on signalment, weight, body condition, medical history, concurrent disease, and results of histopathologic examination was obtained by reviewing medical records. Logistic regression analysis included calculation of univariate and multivariate (adjusted) odds ratios and 95% confidence intervals. Results and Clinical Implications - Dogs with fatal acute pancreatitis were largely middle-to older-aged dogs. Risk of developing fatal acute pancreatitis was increased by overweight body condition, diabetes mellitus, hyperadrenocorticism, hypothyroidism, prior gastrointestinal tract disease, and epilepsy. Additionally, Yorkshire Terriers were at increased risk, and Labrador Retrievers and Miniature Poodles were at decreased risk, of developing fatal acute pancreatitis. Males and neutered females appeared to have an increased risk of developing fatal acute pancreatitis, compared with sexually intact females. Thrombus formation was more likely in dogs that developed fatal acute pancreatitis than in control dogs.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalJournal of the American Veterinary Medical Association
Volume214
Issue number1
StatePublished - Jan 1 1999

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pancreatitis
Pancreatitis
risk factors
Dogs
dogs
body condition
Adrenocortical Hyperfunction
Newfoundland and Labrador
medical history
Poodle (dog breed)
hyperadrenocorticism
Labrador Retriever
hypothyroidism
epilepsy
Gastrointestinal Diseases
risk reduction
diabetes mellitus
Hypothyroidism
case-control studies
odds ratio

Cite this

Evaluation of risk factors for fatal acute pancreatitis in dogs. / Hess, Rebecka S.; Kass, Philip H.; Shofer, Frances S.; Van Winkle, Thomas J.; Washabau, Robert J.

In: Journal of the American Veterinary Medical Association, Vol. 214, No. 1, 01.01.1999, p. 46-51.

Research output: Contribution to journalReview article

Hess, Rebecka S. ; Kass, Philip H. ; Shofer, Frances S. ; Van Winkle, Thomas J. ; Washabau, Robert J. / Evaluation of risk factors for fatal acute pancreatitis in dogs. In: Journal of the American Veterinary Medical Association. 1999 ; Vol. 214, No. 1. pp. 46-51.
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