Evaluation of rapid diagnostic tests for assessment of hepatitis b in resource-limited settings

James S. Leathers, M. Belen Pisano, Viviana Re, Gertine van Oord, Amir Sultan, Andre Boonstra, Jose D. Debes

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Chronic Hepatitis B (HBV) is the most important cause of liver disease worldwide. There is a need for low-cost tests to aid in diagnosis and management of HBV infection in resource-limited settings. We evaluated the utility of several rapid diagnostic tests (RDT) in three different continents (Europe, South America, Africa). The HBsAg RDT showed optimal sensitivity and specificity. The anti-HBeAb RDT showed acceptable sensitivity and excellent specificity. Our results suggest that these RDTs could be used for screening and management of HBV.

Original languageEnglish (US)
Article number98
JournalAnnals of global health
Volume85
Issue number1
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
This work was supported by the Doris Duke International Clinical Research Fellowship Program at the University of Minnesota to JL, the Robert Wood Johnson Foundation, AFMDP, Mitialto Foundation and NIH-NCI R21 CA215883-01A1 all to JDD. Funding sponsors had no role in the production of this manuscript.

Funding Information:
This work was supported by the Doris Duke International Clinical Research Fellowship Program at the University of Minnesota to JL, the Robert Wood Johnson Foundation, AFMDP, Mitialto Foundation and NIH-NCIR21 CA215883-01A1 all to JDD. Funding sponsors had no role in the production of this manuscript.

Publisher Copyright:
© 2019, Ubiquity Press. All rights reserved.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

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