Evaluation of molecular models for the affinity maturation of antibodies: Roles of cytosine deamination by AID and DNA repair

Mala Samaranayake, Janusz M. Bujnicki, Michael Carpenter, Ashok S. Bhagwat

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

This review focuses on the humoral response and the progress made in the field since 1999. First, description of some aspects of the immune response relevant to these alterations and a series of programmed DNA alterations initiated by an enzyme, activation-induced deaminase (AID), that are essential for an effective immune response is presented. Enumerated and discussed are: the discovery, biology, structure, and enzymatic activity of AID; role of DNA repair in somatic hypermutation (SHM); mutagenesis by AID; role of transcription in SHM; models for how AID may target transcribing genes; antibody maturation and cancer; and antibody maturation and molecular evolution.

Original languageEnglish (US)
Pages (from-to)700-719
Number of pages20
JournalChemical Reviews
Volume106
Issue number2
DOIs
StatePublished - Feb 2006

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